55155-23-2Relevant articles and documents
Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
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, (2008/06/13)
Compounds of the formula STR1 wherein R5 represents C1 to C6 -alkyl or the group--(CH2)n --Z--(CH2)m --Ar wherein Z represents O, S or --CH2 --and Ar is phenyl, optionally substituted by one or two groups selected from the group consisting of hydrogen, C1 to C6 -alkyl, C1 to C6 -alkoxy, Cl,F,Br,I,NO2, CF3, CN, R6 -S(O)x, R7 --CO--,(R8 R9)NCO-and phenyl, wherein x is 0, 1 or 2, and each R6, R7, R8 and R9 is independently C1 to C6 alkyl or two adjacent groups on Ar may form together an additional fused benzenoid ring; n and m independently represent integers of from 1 to 8; and ring Q represents one of the rings Q1, Q2, Q3 or Q4 below: STR2 X is N or C--R1 ; Y is N or C--R4 ; W represents O or S; each of R1, R2, R3 and R4 is independently selected from hydrogen, C1 to C6 -alkyl, C1 to C6 -alkoxy, Cl,F,Br,I,NO2,CF3,CN, R10 -S(O)y --, R11 --CO--, (R12 R13)N--CO--or phenyl, wherein y is 0, 1 or 2 and each of SR10, R11, R12 and R13 is independently C1 to C6 -alkyl, or, in the ring Q1, two adjacent groups, i.e. R1 R2, R2 R3 or R3 R4, may form together an additional fused benzenoid ring; and pharmaceutically acceptable acid addition salts of such compounds are described. These compounds provide favorable properties for the treatment of asthma and all types of chronic, obstructionary bronchopulmonary diseases.
