552301-45-8

Basic information

• Product Name: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid
• Synonyms: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid
• CAS NO: 552301-45-8
• Molecular Formula: C12H16O3
• Molecular Weight: 208.25364
• Mol File: 552301-45-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 362.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• PKA: 4.42±0.10(Predicted)
• CAS DataBase Reference: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(552301-45-8)
• EPA Substance Registry System: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(552301-45-8)

Safety Data

• Hazardous Substances Data: 552301-45-8(Hazardous Substances Data)

Usage

General Description

2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid, also known as ibuproxam, is a drug compound that belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). It demonstrates both analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties, making it useful for treating a variety of conditions, including headaches, muscle aches, dental pain, and menstrual cramps. Ibuproxam works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. Despite its benefits, ibuproxam may pose risks of gastrointestinal bleeding, kidney problems, and cardiovascular events in some individuals, and it should only be used under the supervision of a healthcare professional.

Upstream product

• 137756-89-9 4-(2-hydroxy ethyl)phenyl boronic acid 
• 594-58-1 2-chloro-2-methylpropanoic acid 
• 73899-15-7 1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane 
• 4654-39-1 4-bromophenethanol 
• 192775-97-6 4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene 
• 1039038-05-5 C₁₄H₁₈ClNO 

Downstream Products

• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 1181267-37-7 2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester 
• 1000536-33-3 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester 
• 1181267-31-1 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester 

Relevant articles and documents

Preparation method of bilastine intermediate

The invention belongs to the field of medicinal chemistry, and relates to a preparation method of a bilastine intermediate 2-(4-(2-hydroxyethyl) phenyl)-2-methyl propionic acid and derivatives thereof. The 2-(4-(2-hydroxyethyl) phenyl)-2-methyl propionic acid and the derivative thereof are obtained by taking a 4-halogenated phenyl-2-methyl propionic acid derivative as a raw material through the steps of alkylation, hydrolysis, reduction and the like, and the compound can be used for synthesizing bilastine.

Preparation method of new anti-allergic medicine Bilastine intermediate

The invention discloses a preparation method of a new anti-allergic medicine Bilastine intermediate. Quaternary carbon atoms difficult to construct are constructed by using a mild addition reaction, carboxylic groups are introduced at room temperature by