55717-45-8

Basic information

• Product Name: 2-Bromo-5-hydroxypyridine
• Synonyms: 2-BROMO-5-HYDROXYPYRIDINE ,98%;6-Bromo-3-pyridinol;2-BroMo-5-hydnxypyridine;2-BroMo-5-hydroxypyridine, 97+%;2-Bromo-5-hydroxypyridine,95%;2-BROMO-5-HYDROXYPYRIDINE;5-HYDROXY-2-BROMOPYRIDINE;6-BROMO-3-HYDROXYPYRIDINE
• CAS NO: 55717-45-8
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• EINECS: 1533716-785-6
• Product Categories: Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Boronic Acid;Pyridine Series;Heterocycle-Pyridine series;blocks;Bromides;6
• Mol File: 55717-45-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 135.5-136.5°C
• Boiling Point: 373 °C at 760 mmHg
• Flash Point: 179.4 °C
• Appearance: Light yellow Crystal
• Density: 1.788 g/cm³
• Vapor Pressure: 4.3E-06mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.69±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-hydroxypyridine(55717-45-8)
• EPA Substance Registry System: 2-Bromo-5-hydroxypyridine(55717-45-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 55717-45-8(Hazardous Substances Data)

Usage

Description

2-Bromo-5-hydroxypyridine is a pyridine derivative characterized by the presence of a bromine atom at the 2nd position and a hydroxyl group at the 5th position. It is a light yellow crystalline compound with antioxidant properties and is utilized as an active pharmaceutical intermediate in the synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
2-Bromo-5-hydroxypyridine is used as an active pharmaceutical intermediate for the development of new drugs. Its unique structure allows it to be involved in coupling reactions with halo aromatic amines and alcohols, providing a practical synthetic route to 2-substituted amino phenyl and hydroxyphenyl pyridines, which can be further utilized in the pharmaceutical industry.
Used in Chemical Synthesis:
2-Bromo-5-hydroxypyridine is also used in chemical synthesis as a key building block for the creation of various organic compounds. Its antioxidant properties make it a valuable component in the development of new materials with potential applications in different industries.
Used in Antioxidant Applications:
Due to its antioxidant properties, 2-Bromo-5-hydroxypyridine can be employed in various applications where antioxidants are required, such as in the food and cosmetics industries, to prevent oxidation and extend the shelf life of products.

InChI:InChI=1/C5H4BrNO/c6-5-2-1-4(8)3-7-5/h1-3,8H

Upstream product

• 42834-01-5 2-bromo-5-ethoxy-pyridine 
• 223463-14-7 6-bromopyridin-3-ylboronic acid 
• 214360-62-0 2-[(6-bromo)pyridin-3-yl]-4,4',5,5'-tetramethyl-1,3-dioxaborolane 
• 624-28-2 2,5-dibromopyridine 
• 186593-28-2 5-acetoxy-2-bromopyridine 
• 13534-97-9 6-bromopyridine-3-amine 
• 4487-59-6 2-bromo-5-nitropyridine 

Downstream Products

• 6602-34-2 2,4,6-tribromo-3-hydroxypyridine 
• 129034-38-4 5-hydroxy-2-iodopyridine 
• 105170-27-2 2-bromo-5-methoxypyridine 
• 886980-61-6 2-bromo-5-(methoxymethoxy)pyridine 
• 803733-32-6 benzyl-ethyl-(5-methoxy-pyridin-2-yl)-amine 
• 803733-31-5 (5-methoxy-pyridin-2-yl)-(1-phenyl-propyl)-amine 
• 857429-81-3 4,6-dibromo-pyridin-3-ol 
• 888327-36-4 2-bromo-5-(trifluoromethoxy)pyridine 
• 1039046-54-2 4-(6-bromopyridin-3-yloxy)-7-methoxyquinoline 
• 630120-99-9 5-(benzyloxy)-2-bromopyridine 
• 1144110-15-5 2-bromo-5-propoxy-pyridine 
• 1144110-16-6 2-bromo-5-(cyclopentyloxy)pyridine 
• 1144110-18-8 2-bromo-5-(4-methanesulfonyl-phenoxy)-pyridine 
• 1114235-29-8 toluene-4-sulfonic acid 6-bromo-pyridin-3-yl ester 

Relevant articles and documents

Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols

A V2O5@TiO2 catalyzed green and efficient protocol for the hydroxylation of boronic acid into phenol has been developed utilizing environmentally benign oxidant hydrogen peroxide. A wide range of electron-donating and the electron-withdrawing group-containing (hetero)aryl boronic acids were transformed into their corresponding phenol. The methodology was also applied successfully to transform various natural and bioactive molecules like tocopherol, amino acids, cinchonidine, vasicinone, menthol, and pharmaceuticals such as ciprofloxacin, ibuprofen, and paracetamol. The other feature of the methodology includes gram-scale synthetic applicability, recyclability, and short reaction time.

4-((6-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION

Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1- difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.

Synthesis of 9,9′-Spirobifluorenes and 4,5-Diaza-9,9′-spirobifluorenes and Their Application as Affinity Materials for Quartz Crystal Microbalances

Two different classes of aza analogues of 9,9′-spirobifluorenes have been synthesized. These were obtained by either furnishing the spirobifluorene with additional pyridyl moieties or by installing the aza function directly into the spirobifluorene core. These structurally rigid compounds were then evaluated as affinity materials for quartz crystal microbalances and proved to be highly potent for the detection of volatile organic compounds.