55942-61-5

Basic information

• Product Name: 2-(PhenoxyMethyl)nicotinic acid
• Synonyms: 2-(PhenoxyMethyl)nicotinic acid
• CAS NO: 55942-61-5
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23134
• Mol File: 55942-61-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(PhenoxyMethyl)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PhenoxyMethyl)nicotinic acid(55942-61-5)
• EPA Substance Registry System: 2-(PhenoxyMethyl)nicotinic acid(55942-61-5)

Safety Data

• Hazardous Substances Data: 55942-61-5(Hazardous Substances Data)

Usage

Physical Appearance

White solid

Molecular Weight

255.26 g/mol

Biological Activities

+ Anti-cancer
+ Anti-inflammatory
+ Anti-bacterial
+ Potential anti-diabetic and anti-hypertensive effects

Synthesis

Multistep process involving the reaction of nicotinic acid with phenoxyacetic acid and a suitable base

Potential Applications

+ Lead compound for the development of new drugs
+ Use in the field of pharmaceuticals and agrochemicals
+ Diverse pharmacological activities make it a promising candidate for further research and development.

Upstream product

• 113301-83-0 ethyl 2-(phenoxymethyl)nicotinate 
• 624-67-9 Propargylic aldehyde 
• 5657-51-2 7H-furo[3,4-b]pyridin-5-one 
• 108-95-2 phenol 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 81113-14-6 2-hydroxymethyl-3-pyridinecarboxylic acid 
• 63050-11-3 ethyl 2-bromomethylpyridine-3-carboxylate 
• 116986-08-4 methyl 2-(bromomethyl)pyridine-3-carboxylate 
• 65719-09-7 methyl 2-methylnicotinate 

Relevant articles and documents

Azacyclo diketone compound and preparation method thereof

The invention provides an azacyclo diketone compound, which is a compound represented by the following structure defined in the specification, or a pharmaceutically acceptable salt thereof. The invention provides a compound having an inhibitory activity on influenza (flu) virus proliferation, particularly on influenza-related cap-dependent endonuclease to inhibit influenza virus proliferation so as to treat or prevent influenza. The present invention relates to a substituted azacyclo diketone compound having inhibitory activity on cap-dependent endonuclease, and a pharmaceutical composition containing the substituted azacyclo diketone compound.

A facile synthesis of substituted 5,11-dihydro[1]benzoxepino[3,4-b]pyridines

5-Amino-5,11-dihydro[1]benzoxepino[3,4-b]pyridines (1) show anti-ulcer and antiarrhythmic activity. An efficient method for the preparation of a key intermediate, furo[3,4-b]pyridin-5(7H)-one (4), and the facile synthesis of 1 were described. The reduction of quinolinic anhydride (5) with sodium borohydride in the presence of acetic acid regioselectively gave the lactone 4. Lactone 4 was then reacted with substituted phenols under basic conditions and the resultant products, 2-(phenoxymethyl)-3-pyridinecarboxylic acids (3), underwent Friedel-Crafts cyclizations to produce the 5,11-dihydro[1]benzoxepino[3,4-b]pyridin-5-ones (2). Compounds 2 were then converted to imines with amines and successively reduced with zinc in acetic acid to the desired compounds 1.

Nonsteroidal antiinflammatory agents. IV. Syntheses of pyridobenzoxepin, pyridobenzothiepin and their acetic acid derivatives

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