56041-75-9

Basic information

• Product Name: 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol
• Synonyms: 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol;4-Bromo-α-cyclopropyl-α-methylbenzenemethanol;Einecs 259-955-9;1-(4-bromophenyl)-1-cyclopropylethanol
• CAS NO: 56041-75-9
• Molecular Formula: C₁₁H₁₃BrO
• Molecular Weight: 241.12432
• EINECS: 259-955-9
• Mol File: 56041-75-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 326.6°Cat760mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.482g/cm³
• Vapor Pressure: 8.67E-05mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol(56041-75-9)
• EPA Substance Registry System: 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol(56041-75-9)

Safety Data

• Hazardous Substances Data: 56041-75-9(Hazardous Substances Data)

Usage

General Description

4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol is a chemical compound with the molecular formula C11H13BrO. It is an organic compound that consists of a benzene ring substituted with a bromine atom, a cyclopropane ring, and an alcohol functional group. 4-bromo-alpha-cyclopropyl-alpha-methylbenzyl alcohol is commonly used in organic synthesis and pharmaceutical research as a building block or intermediate in the production of various other chemicals and pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs and other chemical compounds. Additionally, its reactivity and versatility make it an important tool for chemists and researchers in the field of organic chemistry.

InChI:InChI=1/C11H13BrO/c1-11(13,8-2-3-8)9-4-6-10(12)7-5-9/h4-8,13H,2-3H2,1H3

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 75-16-1 methylmagnesium bromide 
• 106-37-6 1.4-dibromobenzene 

Downstream Products

• 65322-32-9 1-bromo-4-(1-cyclopropylvinyl)benzene 
• 65322-29-4 1-(4-Bromo-phenyl)-2,2-dichloro-bicyclopropyl 
• 1360551-88-7 2-(4-bromo-phenyl)-2-cyclopropylpropionitrile 
• 1360552-61-9 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione 
• 1360549-37-6 5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine 
• 1360550-04-4 2-[4-(3-{(1R)-1-[4-(2-aminopyrimidin-5-yl)phenyl]-1-cyclopropylethyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]-N,N-dimethylacetamide 
• 1360550-70-4 5-[4-((R)-1-cyclopropyl-1-{5-[1-(2-dimethylaminoethyl)-1H-pyrazol-4-yl]-[1,2,4]oxadiazol-3-yl}-ethyl)phenyl]pyrimidin-2-ylamine 
• 1360550-78-2 5-[4-((R)-1-{5-[1-(2-aminoethyl)-1H-pyrazol-4-yl]-[1,2,4]oxadiazol-3-yl}-1-cyclopropylethyl)phenyl]pyrimidin-2-ylamine 
• 1360551-91-2 (S)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile 
• 1360551-90-1 (R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile 
• 1360552-09-5 (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide 
• 1360552-08-4 (R)-2-[4-(2-aminopyrimidin-5-yl)phenyl]-2-cyclopropylpropionitrile 
• 1360552-11-9 (R)-2-cyclopropyl-N-hydroxy-2-[4-(2-methylamino-pyrimidin-5-yl)-phenyl]-propionamidine 
• 1360552-10-8 C₁₇H₁₈N₄ 

Relevant articles and documents

Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor

A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separation) for expedient access to the key structural component of 1: the challenging chiral quaternary center. Also highlighted are in situ IR monitoring, condensation to form the 1,2,4-oxadiazole ring, and an efficient Suzuki-Miyaura coupling.

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OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.