6952-89-2

Basic information

• Product Name: (4-BROMOPHENYL)(CYCLOPROPYL)METHANONE
• Synonyms: TIMTEC-BB SBB005772;(4-Bromophenyl)cyclopropylmethanone,95%;Methanone,(4-broMophenyl)cyclopropyl-;4-BROMOPHENYL CYCLOPROPYL KETONE;(4-BROMOPHENYL)(CYCLOPROPYL)METHANONE;4-BROMO-CYCLOPROPYLCARBONYLBENZENE
• CAS NO: 6952-89-2
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• EINECS: 230-130-5
• Mol File: 6952-89-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 40.0 to 44.0 °C
• Boiling Point: 204°C/10mmHg(lit.)
• Flash Point: 100.4 °C
• Appearance: Yellow or beige to orange/Crystalline Powder or Low Melting Crystalline Mass
• Density: 1.45
• Vapor Pressure: 0.00072mmHg at 25°C
• Refractive Index: 1.5919
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (4-BROMOPHENYL)(CYCLOPROPYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMOPHENYL)(CYCLOPROPYL)METHANONE(6952-89-2)
• EPA Substance Registry System: (4-BROMOPHENYL)(CYCLOPROPYL)METHANONE(6952-89-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 45-36/37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 6952-89-2(Hazardous Substances Data)

Usage

Chemical Properties

BEIGE TO LIGHT BROWN CRYSTALLINE LOW MELTING SOLID

InChI:InChI=1/C10H9BrO/c11-9-5-3-8(4-6-9)10(12)7-1-2-7/h3-7H,1-2H2

Upstream product

• 108-86-1 bromobenzene 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 5467-74-3 4-Bromophenylboronic acid 
• 5500-21-0 cyclopropropanecarbonitrile 
• 106-37-6 1.4-dibromobenzene 
• 147356-78-3 cyclopropanecarboxylic acid N-methoxy-N-methylamide 

Downstream Products

• 70289-39-3 1-((4-bromophenyl)(hydroxy)methyl)cyclopropane 
• 93765-50-5 (4-Bromo-phenyl)-cyclopropyl-pyrimidin-5-yl-methanol 
• 170564-99-5 4-cyanophenylcyclopropylmethanone 
• 575469-33-9 (E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid methyl ester 
• 575469-35-1 (E)-3-(4-(cyclopropylcarbonyl)phenyl)acrylic acid 
• 340188-25-2 4-(R,S)-(4-cyanophenyl)-4-cyclopropyl-2,5-dioxoimidazolidine 
• 340188-28-5 [4-(R,S)-(4-cyanophenyl)-4-cyclopropyl-2,5-dioxoimidazolidin-1-yl]acetic acid methyl ester 
• 880088-78-8 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid, methyl ester 
• 168907-66-2 4'-bromo-4-iodobutyrophenone 
• 179251-28-6 1-Bromo-4-(cyclopropylmethyl)-benzene 
• 1109231-85-7 1-(4-bromophenyl)-1-cyclopropyl-3-phenylprop-2-yn-1-ol 
• 56041-75-9 1-(4-bromophenyl)-1-cyclopropylethan-1-ol 
• 1360552-61-9 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione 
• 1360549-37-6 5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine 

Relevant articles and documents

NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS

The present invention relates to inhibitors of apoptosis signal-regulating kinase 1 ("ASK1"), a process for synthesis of the compounds of the present invention, composition comprising the compounds and use of the compounds for inhibition of ASK1.

B(C6F5)3-Catalyzed Hydrosilylation of Vinylcyclopropanes

A hydrosilylation of vinylcyclopropanes (VCPs) catalyzed by the strong boron Lewis acid B(C6F5)3 is reported. For the majority of VCPs, little or no ring opening of the cyclopropyl unit is observed. Conversely, for VCPs with bulky R groups, such as ortho-substituted aryl rings or branched alkyl residues, ring opening is the exclusive reaction pathway. This finding is explained by the thwarted hydride delivery to a sterically shielded, β-silicon-stabilized cyclopropylcarbinyl cation intermediate.

Mild Ring Contractions of Cyclobutanols to Cyclopropyl Ketones via Hypervalent Iodine Oxidation

An iodine-mediated oxidative ring contraction of cyclobutanols has been developed. The reaction allows the synthesis of a wide range of aryl cyclopropyl ketones under mild and eco-friendly conditions. A variety of functional groups including aromatic or alkyl halides, ethers, esters, ketones, alkenes, and even aldehydes are nicely tolerated in the reaction. This is in contrast with traditional synthetic approaches for which poor functional group tolerance is often a problem. The practicality of the method is also highlighted by the tunability of iodine oxidation system. Specifically, combining the iodine(III) reagent with an appropriate base allows the reaction to accommodate a range of challenging electron-rich arene substrates. The facile scalability of this reaction is also exhibited herein. (Figure presented.).