568-76-3

Basic information

• Product Name: gamma-hydroxyphenylbutazone
• Synonyms: gamma-hydroxyphenylbutazone;1,2-Diphenyl-4-(3-hydroxybutyl)-3,5-pyrazolidinedione;4-(3-Hydroxybutyl)-1,2-diphenylpyrazolidine-3,5-dione;G-28231;γ-Hydroxykebuzone;1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine;3,5-Pyrazolidinedione, 1,2-diphenyl-4-(3-hydroxybutyl)-;3,5-Pyrazolidinedione, 4-(3-hydroxybutyl)-1,2-diphenyl- (9ci)
• CAS NO: 568-76-3
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.37
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 568-76-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 467.5°Cat760mmHg
• Flash Point: 236.6°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 1.53E-09mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: gamma-hydroxyphenylbutazone(CAS DataBase Reference)
• NIST Chemistry Reference: gamma-hydroxyphenylbutazone(568-76-3)
• EPA Substance Registry System: gamma-hydroxyphenylbutazone(568-76-3)

Safety Data

• Hazardous Substances Data: 568-76-3(Hazardous Substances Data)

Usage

Description

Gamma-hydroxyphenylbutazone, also known as γ-Hydroxy Phenylbutazone, is a metabolite of the antirheumatic drug Kebuzone. It is characterized by its chemical structure and pharmacological properties, which contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Gamma-hydroxyphenylbutazone is used as an active metabolite for its anti-inflammatory and analgesic properties. It is particularly effective in the treatment of rheumatic conditions, where it helps to alleviate pain and reduce inflammation.
Used in Research and Development:
In the field of pharmaceutical research and development, gamma-hydroxyphenylbutazone serves as a valuable compound for studying the mechanisms of action and potential therapeutic applications of related drugs. Its metabolite status allows researchers to investigate the pharmacokinetics, pharmacodynamics, and safety profiles of its parent drug, Kebuzone, and other similar compounds.
Used in Drug Metabolism Studies:
Gamma-hydroxyphenylbutazone is utilized as a model compound in drug metabolism studies, providing insights into the metabolic pathways and enzyme interactions involved in the conversion of prodrugs to their active metabolites. This information is crucial for the design and optimization of new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C19H20N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,14,17,22H,12-13H2,1H3

Upstream product

• 122-66-7 diphenyl hydrazine 
• 116604-64-9 4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione 
• 7796-23-8 (3-oxybutyl)malonate ethylene ketal 
• 110-91-8 morpholine 
• 67-56-1 methanol 
• 96740-75-9 6-methyl-2-oxo-tetrahydro-pyran-3-carboxylic acid-(N,N'-diphenyl-hydrazide) 
• 853-34-9 kebuzone 

Relevant articles and documents

Contraceptive method

Contraceptive method comprises maintaining in the genital tract of a female mammal a pyrazolone derivative in a concentration effective to inhibit the fertilization of ova. In addition to effectively inhibiting the enzymes or other sperm components necessary for conception, the compounds used in the method of the invention are advantageous in having low toxic, caustic or irritating properties, so that the contraceptive compositions are suitable for long-term use without adverse side-effects.