853-34-9 Usage
Description
KETOPHENYLBUTAZONE, also known as phenylbutazone with an oxo group replacing the two methylene hydrogens at position 3 on the butyl chain, is a pyrazolidine derivative. It is a pharmaceutical compound with various applications in the medical field.
Uses
Used in Pharmaceutical Industry:
KETOPHENYLBUTAZONE is used as an anti-inflammatory and analgesic agent for the treatment of various conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It helps in reducing pain, inflammation, and stiffness associated with these conditions.
Used in Veterinary Medicine:
In the veterinary industry, KETOPHENYLBUTAZONE is used as an anti-inflammatory and analgesic agent for the treatment of pain and inflammation in animals. It is commonly used in horses, dogs, and cats to manage conditions such as arthritis, sprains, and other musculoskeletal disorders.
Brand Names:
Some of the brand names under which KETOPHENYLBUTAZONE is marketed include Benjor, Chebutan, Chepirol, Chetazolidin, Chetosol, Copirene, Gammachetone, Hichillos, Kentan-s, Kenta-s, Kenzon r, Ketobutane-jade, Ketofen, Neo-panalgyl, Neufenil, Neuphenyl, Phloguron, Recheton, Reuchetal, Reumo, Tkb, Vintab, and Vintop.
Originator
Chebutan,Bioindustria,Italy,1961
Manufacturing Process
(a) 3,3-ethylene dioxyburyl malonic acid diethyl ester: Diethylmalonate is
reacted with methyl vinyl ketone and the resulting oxobutyl diethylmalonate is
reacted with ethylene glycol.(b) 1,2-diphenyl-4-(3',3'-ethylene dioxybutyl)3,5-dioxopyrazolidine: 274 parts
of (3,3-ethylene dioxybutyl)-malonic acid diethyl ester are dissolved in 100
parts by volume of abs. benzene and 57 parts of sodium ethylate and 184
parts of hydrazobenzene are added. Heat is generated. The reaction mass is
boiled for 15 hours under reflux. After cooling, it is poured into water,
separated and the aqueous part is washed twice with benzene. The benzene
solutions are washed three times with 2N sodium carbonate solution and the
unified aqueous solutions are acidified with 2N hydrochloric acid. The 1,2-
phenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine which precipitates
can be recrystallized from alcohol. Melting point 165°C to 167°C.(c) 1,2-diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine: 36.6 parts of 1,2-
diphenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine in 750 parts byvolume of acetone are boiled under reflux for 18 hours with 0.35 part of ptoluene sulfonic acid. The solution is then filtered, 1,500 parts of water are
added and the whole is allowed to stand for 24 hours at 5°C. The 1,2-
diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine which precipitates is filtered off
under suction and washed with 50% acetone. Melting point from alcohol/water
mixture: 115.5°C to 116.5°C. Sometimes a crystal form is obtained which
melts at 127.5°C to 128.5°C.
World Health Organization (WHO)
Kebuzone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1973 for the treatment of
rheumatic disorders. As it is structurally related to phenylbutazone it is subjected
to rigorously restricted indications by some national regulatory authorities. See
WHO comment for phenylbutazone.
Check Digit Verification of cas no
The CAS Registry Mumber 853-34-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,5 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 853-34:
(5*8)+(4*5)+(3*3)+(2*3)+(1*4)=79
79 % 10 = 9
So 853-34-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3
