5770-49-0

Basic information

• Product Name: 6-(benzylamino)-1,3-dimethyl-pyrimidine-2,4-quinone
• Synonyms: 1,3-dimethyl-6-(phenylmethylamino)pyrimidine-2,4-dione;6-(benzylamino)-1,3-dimethyl-pyrimidine-2,4-quinone
• CAS NO: 5770-49-0
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.2771
• Mol File: 5770-49-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 388.7°C at 760 mmHg
• Flash Point: 188.9°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 3E-06mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 6-(benzylamino)-1,3-dimethyl-pyrimidine-2,4-quinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(benzylamino)-1,3-dimethyl-pyrimidine-2,4-quinone(5770-49-0)
• EPA Substance Registry System: 6-(benzylamino)-1,3-dimethyl-pyrimidine-2,4-quinone(5770-49-0)

Safety Data

• Hazardous Substances Data: 5770-49-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H15N3O2/c1-15-11(8-12(17)16(2)13(15)18)14-9-10-6-4-3-5-7-10/h3-8,14H,9H2,1-2H3

Upstream product

• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 
• 100-46-9 benzylamine 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 21544-68-3 4,6-dimethyl-2-phenyl-4H-thiazolo[4,5-d]pyrimidine-5,7-dione 
• 89367-55-5 C₂₇H₃₀N₆O₄ 
• 105159-32-8 4-methyl-N-(2-phenyl-2-(phenylamino)ethyl)benzenesulfonamide 
• 105205-04-7 N-{2-[4-(6-Benzylamino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide 
• 105159-23-7 6-Benzylamino-1,3-dimethyl-5-{4-[5-phenyl-3-(toluene-4-sulfonyl)-imidazolidin-1-yl]-benzyl}-1H-pyrimidine-2,4-dione 
• 109507-50-8 6-benzylamino-5-bromo-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 932726-19-7 6-benzylamino-5-[3-(4-bromophenyl)-3-oxopropyl]-1,3-dimethyluracil 
• 961-45-5 1,3-dimethyl-8-phenylxanthine 
• 1257251-84-5 7'-benzyl-1',3'-dimethyl-3H-spiro[isobenzofuran-1,6'-pyrrolo[2,3-d]pyrimidine]-2',3,4',5'(1'H,3'H,7'H)-tetraone 
• 1448800-39-2 6-(benzylamino)-1,3-dimethyl-5-(trifluoroacetyl)pyrimidine-2,4(1H,3H)-dione 
• 1448800-57-4 6,8-dimethyl-2-phenyl-4-(trifluoromethyl)-4,8-dihydro-2H-pyrimido[4,5-d][1,3]oxazine-5,7(1H,6H)-dione 

Relevant articles and documents

Selective N-Monoalkylation of 6-Aminouracils with Alcohols: An Environmentally Benign Protocol for the Synthesis of 6-Alkylaminouracils

A highly selective N-alkylation of 6-aminouracils with alcohols was achieved through the borrowing hydrogen approach using iridium catalysis. 6-Aminouracils and alcohols reacted in the presence of [Cp*IrI2]2 to give 6-monoalkyluracils selectively and in high yield (up to 99 %), usually in short reaction times (2 h). These results provide a new, green, and efficient protocol for the synthesis of 6-alkylaminouracils, which are very important intermediates for the synthesis of biologically active molecules.

Two-step synthetic approach to 6-substituted pyrido[2,3-d]pyrimidine(1H,3H) -2,4-diones from 6-amino-, 6-alkylamino-, and 6-arylamino-1,3-dimethyluracils

The Mannich reaction of 7-aryl-5,6-dihydropyrido[2,3-d]pyrimidines 3, easily accessible by condensation of 6-amino-1,3-dimethyluracil (1) with Mannich bases 2a-c, gives rise to a mixture of 7-aryl-6-(N,N-dimethylaminomethyl) pyrido[2,3-d]pyrimidines 6 and

3,3-Sigmatropic rearrangements involving N-O bond-cleavage of enehydroxylamine derivatives

Enehydroxylamines, derived from carbocyclic and heterocyclic 1,3-dioxo compounds, react with a variety of unsaturated electrophiles to give, in good to excellent yields, substances that in general undergo 3,3-sigmatropic rearrangements either spontaneously or upon heating. In those cases in which such reactions failed, addition of sodium hydride was found to induce the transformation. A study of the rearrangement by use of deuterium-labelled compounds showed that no crossover occurs, indicating the intramolecular nature of the process. The method provides 2,3- or 3,4-disubstituted cyclohexenones, 5,6-disubstituted barbiturates and the corresponding fused pyrrole and imidazolinone derivatives. Wiley-VCH Verlag GmbH & Co KGAA, 69451 Weinheim, Germany, 2003.