57710-80-2

Basic information

• Product Name: 1-(BENZYLOXYCARBONYL)BENZOTRIAZOLE
• Synonyms: LABOTEST-BB LT00645599;BENZYL 1-BENZOTRIAZOLECARBOXYLATE;1-Z-BENZOTRIAZOLE;1-(BENZYLOXYCARBONYL)BENZOTRIAZOLE;Z-BENZOTRIAZOLE;Benzyl 1-benzotriazolecarboxylate, Z-benzotriazole;Z-benzotriazole99.0 +%;1-(Benzyloxycarbonyl)Benzotriazole(WXC03095)
• CAS NO: 57710-80-2
• Molecular Formula: C₁₄H₁₁N₃O₂
• Molecular Weight: 253.26
• Mol File: 57710-80-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 107-109 °C
• Boiling Point: 427.3°C at 760 mmHg
• Flash Point: 212.2°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.65E-07mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(BENZYLOXYCARBONYL)BENZOTRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(BENZYLOXYCARBONYL)BENZOTRIAZOLE(57710-80-2)
• EPA Substance Registry System: 1-(BENZYLOXYCARBONYL)BENZOTRIAZOLE(57710-80-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 4.10-10-21
• Hazardous Substances Data: 57710-80-2(Hazardous Substances Data)

Usage

Uses

Reagent for introducing the Z-protecting group (carbobenzoxy group)

InChI:InChI=1/C14H11N3O2/c18-14(19-10-11-6-2-1-3-7-11)17-13-9-5-4-8-12(13)15-16-17/h1-9H,10H2

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 501-53-1 benzyl chloroformate 
• 68985-05-7 1,1′-carbonylbis-benzotriazole 
• 100-51-6 benzyl alcohol 
• 43183-36-4 1-(trimethylsilyl)-1H-benzotriazole 
• 88-74-4 2-nitro-aniline 
• 23091-35-2 (2-nitrophenyl)carbamic acid benzyl ester 
• 22706-01-0 (2-amino-phenyl)carbamic acid benzyl ester 

Downstream Products

• 7107-58-6 benzyl N-cyclohexylcarbamate 
• 18807-67-5 1,2-Ethanediylbis(phenylmethyl carbamate) 
• 65095-17-2 N-(benzyloxycarbonyl)propylamine 
• 1142-20-7 N-Cbz-Ala 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 19728-63-3 N-benzyloxycarbonyl-L-treonine 
• 1161-13-3 N-Cbz-L-Phe 
• 117860-58-9 methyl 3-<(benzyloxycarbonyl)amino>-1-methylpyrazole-5-carboxylate 
• 66519-70-8 2-benzyl-2H-benzo[d][1,2,3]triazole 
• 4706-43-8 1-benzyl-1H-benzotriazole 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 621-84-1 O-benzyl carbamate 
• 63914-51-2 [(4-cyanophenyl)methyl]-carbamic acid phenylmethyl ester 
• 131829-26-0 (S)-2-(((benzyloxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid 

Relevant articles and documents

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.

STUDIES ON THE THERMAL DECARBOXYLATION OF 1-ALKOXYCARBONYLBENZOTRIAZOLES

1-Alkoxycarbonylbenzotriazoles on thermolysis lose carbon dioxide; the decarboxylation is accompanied by the formation of a mixture of 1- and 2-alkylbenzotriazoles, with the N-1 isomer predominating over the N-2 isomer in all cases.A cross-over experiment

Antiinflammatory agents. III. Synthesis and screening of benzotriazole derivatives with aromatic substituents

-