5814-37-9

Basic information

• Product Name: ethyl 2.4-dioxo-4-p-tolylbutanoate
• Synonyms: ethyl 2.4-dioxo-4-p-tolylbutanoate;Benzenebutanoic acid, 4-Methyl-.alpha.,.gaMMa.-dioxo-, ethyl ester;Ethyl 4-Methyl-a,g-dioxo-benzenebutanoate;Ethyl 2,4-dioxo-4-(p-tolyl)
• CAS NO: 5814-37-9
• Molecular Formula: C₁₃H₁₄O₄
• Molecular Weight: 234
• Mol File: 5814-37-9.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: ethyl 2.4-dioxo-4-p-tolylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2.4-dioxo-4-p-tolylbutanoate(5814-37-9)
• EPA Substance Registry System: ethyl 2.4-dioxo-4-p-tolylbutanoate(5814-37-9)

Safety Data

• Hazardous Substances Data: 5814-37-9(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-dioxo-4-p-tolylbutanoate is a chemical compound that belongs to the ester class of organic compounds. It is derived from the reaction of 4-methylbenzoyl chloride and ethyl acetoacetate in the presence of a base catalyst. ethyl 2.4-dioxo-4-p-tolylbutanoate is used in the synthesis of pharmaceuticals and as a flavoring agent in the food industry. It has a fruity, apple-like odor and is commonly found in cosmetic and personal care products. Ethyl 2,4-dioxo-4-p-tolylbutanoate is also used in the production of fragrances and as a solvent in various industrial applications. However, it is important to handle this chemical with caution as it may be hazardous if not used properly.

Upstream product

• 122-00-9 para-methylacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 104-87-0 4-methyl-benzaldehyde 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 

Downstream Products

• 55558-81-1 4-(4-methylphenyl)-2,4-dioxobutanoic acid 
• 5842-78-4 1,1-dioxo-5-p-tolyl-1,2(6)-dihydro-1λ⁶-[1,2,6]thiadiazine-3-carboxylic acid ethyl ester 
• 112080-19-0 C₃₄H₃₀N₆O₄ 
• 83715-73-5 3-Methylsulfanyl-6-(2-oxo-2-p-tolyl-ethyl)-4H-[1,2,4]triazin-5-one 
• 89569-83-5 3-Mercapto-6-(2-oxo-2-p-tolyl-ethyl)-2H-[1,2,4]triazin-5-one 
• 88958-15-0 ethyl 5-(4-methylphenyl)isoxazole-3-carboxylate 
• 640292-02-0 5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde 
• 640291-93-6 [5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol 
• 640292-09-7 2-[hydroxy-(5-p-tolylisoxazol-3-yl)methyl]acrylic acid methyl ester 
• 89569-80-2 6-p-Tolyl-thieno[2,3-e][1,2,4]triazine-3-thiol 
• 83715-56-4 3-Methylsulfanyl-6-p-tolyl-thieno[2,3-e][1,2,4]triazine 
• 83715-61-1 3-Piperidin-1-yl-6-p-tolyl-thieno[2,3-e][1,2,4]triazine 
• 83715-58-6 3-Morpholin-4-yl-6-p-tolyl-thieno[2,3-e][1,2,4]triazine 

Relevant articles and documents

Lewis acid-promoted synthesis of highly substituted pyrrole-fused benzoxazinones and quinoxalinones

A synthesis of a series of novel fused tricyclic heterocyclic compounds has been achieved in one-pot reaction set up starting from (E)-3-(2-oxo-2-phenylethylidene)indolin-2-one and 1,4-benzoxazinone/quinoxalinone derivatives promoted by tin(IV) chloride.

Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based inhibitors is in high demand. Objective: Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids possessing α-glucosidase inhibitory activity were developed. Methods: Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3-carboxylic acids and ethyl 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evalu-ated for their α-glucosidase inhibitory activity. Results: It was found that ethyl 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5j) was the most potent compound (IC50 = 180.1 μM) compared with acarbose as the reference drug (IC50 = 750.0 μM). Also, the kinetic study of 5j revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Conclusion: Good α-glucosidase inhibitory activity obtained by the title compounds introduced them as an efficient scaffold, which merits to be considered in anti-diabetic drug discovery developments.

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-