640291-93-6

Basic information

• Product Name: (5-P-TOLYLISOXAZOL-3-YL)METHANOL
• Synonyms: SALOR-INT L482706-1EA;(5-P-TOLYLISOXAZOL-3-YL)METHANOL;AKOS PAO-1440;5-(4-METHYLPHENYL)-3-ISOXAZOLEMETHANOL;[5-(4-methylphenyl)isoxazol-3-yl]methanol(SALTDATA: FREE);[5-(4-methylphenyl)-1,2-oxazol-3-yl]methanol
• CAS NO: 640291-93-6
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 640291-93-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-P-TOLYLISOXAZOL-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-P-TOLYLISOXAZOL-3-YL)METHANOL(640291-93-6)
• EPA Substance Registry System: (5-P-TOLYLISOXAZOL-3-YL)METHANOL(640291-93-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 640291-93-6(Hazardous Substances Data)

Usage

General Description

The chemical (5-P-tolylisoxazol-3-yl)methanol is a compound that consists of a tolyl group attached to an isoxazolyl ring, with a methanol group attached to the isoxazol ring. It is used in scientific research as a building block for the synthesis of various organic compounds. This chemical has potential applications in the development of pharmaceuticals, agrochemicals, and materials science due to its unique structure and reactivity. Additionally, it may also have properties that make it useful in the field of medicinal chemistry for the development of new drugs. However, further research is needed to fully understand and harness the potential of this compound.

Upstream product

• 5814-37-9 ethyl-4-(4-methylphenyl)-2,4-dioxobutyrate 
• 122-00-9 para-methylacetophenone 
• 640292-02-0 5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde 
• 1361109-69-4 3-hydroxyiminomethyl-5-p-tolylisoxazole 
• 517870-14-3 methyl 5-(p-tolyl)isoxazole-3-carboxylate 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 39757-29-4 methyl 2,4-dioxo-4-p-tolylbutanoate 

Downstream Products

• 640292-02-0 5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde 
• 1378938-21-6 2-amino-3-cyano-7-dimethylamino-4-(5-(4-methylphenyl)-isoxazol-3-yl)-4H-chromene 

Relevant articles and documents

Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies

The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing the 150-cavity which is nascent to the activity site of NA. NA inhibitory studies showed that new derivatives demonstrated the inhibitory activity with IC50 values at nM level against NA of a clinical influenza virus strain. Moreover, the in silico ADME predictions showed that the selected compounds had comparable properties with oseltamivir carboxylate, which demonstrated the druggablity of these derivatives. Furthermore, molecular docking studies showed that the most potent compound 6f and 10i could adopt different modes of binding interaction with NA, which may provide novel solutions for treating oseltamivir-resistant influenza. Based on the research results, we consider that compounds 6f and 10i have the potential for further studies as novel antiviral agents.

Substituted 1-(isoxazol-3-yl)methyl-1H-1,2,3-triazoles: Synthesis, palladium(II) complexes, and high-turnover catalysis in aqueous media

New substituted 3-((1H-1,2,3-triazol-1-yl)methyl)-5-arylisoxazoles (aryl = Ph, p-Tol) and 2-(5-phenylisoxazol-3-yl)-5-(2-(1-((5-(p-tolyl)isoxazol-3-yl)methyl)-1H-1,2,3-triazol-4-yl)ethyl)-1,3,4-oxadiazole were synthesized by means of click-chemistry proce

Synthesis of functionally substituted isoxazole and isothiazole derivatives

Acylation of benzene and toluene with 5-phenyl- and 5-(p-tolyl)isoxazole-3- carbonyl chlorides gave 5-phenyl(or p-tolyl)isoxazol-3-yl phenyl(or p-tolyl)ketones which were reduced to the corresponding alcohols with sodium tetrahydridoborate in propan-2-ol. Selective reduction of the carboxy group in 4,5-dichloroisothiazole-3-carboxylic acid was achieved by the action of BH 3, and the aldehyde group in 4-formyl-2-methoxyphenyl 5-arylisoxazole-3-carboxylates and 4,5-dichloroisothiazole-3-carboxylates was reduced to hydroxymethyl group with sodium triacetoxyhydridoborate in benzene. Acylation of the resulting hydroxymethyl derivatives with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides afforded the corresponding esters containing two azole fragments in their molecules.