582319-44-6

Basic information

• Product Name: 2,2,2-Trifluoro-1-(5-methyl-indol-1-yl)-ethanone
• Synonyms: 2,2,2-Trifluoro-1-(5-methyl-indol-1-yl)-ethanone
• CAS NO: 582319-44-6
• Molecular Weight: 227.186
• Mol File: 582319-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2,2-Trifluoro-1-(5-methyl-indol-1-yl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-1-(5-methyl-indol-1-yl)-ethanone(582319-44-6)
• EPA Substance Registry System: 2,2,2-Trifluoro-1-(5-methyl-indol-1-yl)-ethanone(582319-44-6)

Safety Data

• Hazardous Substances Data: 582319-44-6(Hazardous Substances Data)

Upstream product

• 75934-36-0 N-(2,2-Diethoxy-ethyl)-2,2,2-trifluoro-N-p-tolyl-acetamide 

Downstream Products

• 614-96-0 5-methyl-1H-indole 

Relevant articles and documents

SYNTHESIS OF INDOLES FROM N-(TRIFLUOROACETYL)-2-ANILINO ACETALS

N-(trifluoroacetyl)indoles (3) are produced in high yield from appropriately ring-substituted N-(trifluoroacetyl)-2-anilino acetals (2) in boiling trifluoroacetic acid containing excess trifluoroacetic anhydride.Mild saponification provides the free indoles nearly quantitatively.The scope of the reaction is discussed.The ring closure follows solvolytic substitution of a trifluoroacetoxy group for one of the ethoxy groups in 2.The method has been extended to cyclization of N-(trifluoroacetyl)-α-anilinoacetone in hot polyphosphoric acid followed by saponification to yield 3-methylindole.