58764-22-0

Basic information

• Product Name: Benzoic acid, 4-(2-bromo-1-oxopropyl)-, methyl ester
• CAS NO: 58764-22-0
• Molecular Formula: C11H11BrO3
• Molecular Weight: 271.111
• Mol File: 58764-22-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(2-bromo-1-oxopropyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(2-bromo-1-oxopropyl)-, methyl ester(58764-22-0)
• EPA Substance Registry System: Benzoic acid, 4-(2-bromo-1-oxopropyl)-, methyl ester(58764-22-0)

Safety Data

• Hazardous Substances Data: 58764-22-0(Hazardous Substances Data)

Upstream product

• 81631-63-2 p-(methoxycarbonyl)-n-propylbenzene 
• 616-45-5 2-pyrrolidinon 
• 17745-40-3 methyl p-propanoylbenzoate 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 1221065-73-1 (R,E)-methyl 4-(4-(4-methoxyphenyl)-2-methylbut-3-enoyl)benzoate 
• 1221065-63-9 (S,E)-methyl 4-(4-(4-methoxyphenyl)-2-methylbut-3-enoyl)benzoate 
• 860344-48-5 4-[4-(4-methoxycarbonyl-phenyl)-5-methyl-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 58764-20-8 α-(p-Carbomethoxybenzamido)-p-carbmethoxypropiophenone 

Relevant articles and documents

2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas

Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.

PROTEASE INHIBITORS

Compounds of the formula II, wherein R3 is C1-C3 alkyl or C3-C6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R3/

PROTEASE INHIBITORS

Compounds of the formula (II): wherein R2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline; R3 is H, methyl or fluoro; R4 is C1-C6alkyl; E is a bond or thiazolyl, optionally substituted with methyl or fluoro; n is 0 or 1; or a pharmaceutically acceptable salt, N-oxide or hydrate thereof; have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsinK, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.