58905-32-1Relevant articles and documents
Cocrystallization-Induced Spontaneous Deracemization: A General Thermodynamic Approach to Deracemization
Collard, Laurent,Guillot, Michael,Huynen, Sarah,Leyssens, Tom,Riant, Olivier,Robeyns, Koen,de Meester, Joséphine
, p. 11303 - 11306 (2020)
Processes leading to enantiomerically pure compounds are of utmost importance, in particular for the pharmaceutical industry. Starting from a racemic mixture, crystallization-induced diastereomeric transformation allows in theory for 100 percent transformation of the desired enantiomer. However, this method has the inherent limiting requirement for the organic compound to form a salt. Herein, this limitation is lifted by introducing cocrystallization in the context of thermodynamic deracemization, with the process applied to a model chiral fungicide. We report a new general single thermodynamic deracemization process based on cocrystallization for the deracemization of (R,S)-4,4-dimethyl-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)pentan-3-one. This study demonstrates the feasibility of this novel approach and paves the way to further development of such processes.
A 3, 3 - dimethyl - 1 - (1 H - 1, 2, 4 - triazole - 1 - yl) d - 2 - ketone (by machine translation)
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Paragraph 0027; 0030; 0033; 0035; 0036, (2017/09/13)
The invention discloses a 3, 3 - dimethyl - 1 - (1 H - 1, 2, 4 - triazole - 1 - yl) butan - 2 - one of the preparation method, in order to 4 - amino - 1, 2, 4 - triazole as raw material, in a polar solvent or a polar solvent and in the alkaline environment with a halogen frequency alkone reaction generating onium salt, then the diazotization reaction and hydrolysis to obtain compound 3, 3 - dimethyl - 1 - (1 H - 1, 2, 4 - triazole - 1 - yl) butan - 2 - one. The invention provides a brand new synthetic paclobutrazol intermediate 3, 3 - dimethyl - 1 - (1 H - 1, 2, 4 - triazole - 1 - yl) butan - 2 - one of the method, the method is simple in operation, and high safety factor, it is imperative for the effectively reduces the impurity content of by-products in the product, improve the intermediate 3, 3 - dimethyl - 1 - (1 H - 1, 2, 4 - triazole - 1 - yl) butan - 2 - one quality, to improve the quality of the final product of paclobutrazol, is suitable for marketing production. (by machine translation)
A including wo carboxylic acid ester compound and use thereof
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Paragraph 0171; 0172; 0173, (2017/08/02)
The invention belongs to the field of agricultural herbicides, and concretely relates to an oxime-containing carboxylate compound and a use thereof. The oxime-containing carboxylate compound is represented by general formula (I), has very good weeding activity, can effectively control barnyard grass, piemarker, setaria viridis, Zinnia elegans and other weeds, realizes a very good weeding effect under a low dosage, is highly safe to crops, is especially safe to corn and rice (post-emergence), and can be used as a herbicide in the agricultural field.