58995-86-1Relevant articles and documents
Synthesis of 2-Arylindoles by Rhodium-Catalyzed/Copper-Mediated Annulative Coupling of N-Aryl-2-aminopyridines and Propargyl Alcohols via Selective C-H/C-C Activation
Yan, Xufei,Ye, Runyou,Sun, Huihui,Zhong, Jing,Xiang, Haifeng,Zhou, Xiangge
, p. 7455 - 7459 (2019)
A versatile rhodium-catalyzed/copper-mediated C-H/C-C activation and cascade annulation reaction was described to form 2-arylindole derivatives. Highly selective C-C bond cleavage of ?-substituted tert-propargyl alcohols occurred, together with pyridine-directed ortho C(sp2)-H bond activation, affording a series of 2-arylindoles with yields up to 90%. Subsequent derivations were smoothly conducted to access polyfunctionalized 2-arylindoles, illustrating the potential applications of this method.
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity
Cirrincione, Girolamo,Almerico, Anna Maria,Barraja, Paola,Diana, Patrizia,Lauria, Antonino,Passannanti, Alessandra,Musiu, Chiara,Pani, Alessandra,Murtas, Paola,Minnei, Carla,Marongiu, M. Elena,La Colla, Paolo
, p. 2561 - 2568 (2007/10/03)
Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine 5 were synthesized by diazotization of substituted 2-(2-aminophenyl)indoles followed by an intramolecular coupling reaction of the diazonium group with the indole nitrogen. To obtain the
