4295-28-7

Basic information

• Product Name: 6-methyl-11H-indolo[3,2-c]quinoline
• Synonyms: 11H-Indolo(3,2-c)quinoline, 6-methyl-; 6-Methyl-11H-indolo(3,2-c)quinoline
• CAS NO: 4295-28-7
• Molecular Formula: C₁₆H₁₂N₂
• Molecular Weight: 232.2799
• Mol File: 4295-28-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 467.2°C at 760 mmHg
• Flash Point: 213.9°C
• Density: 1.293g/cm³
• Vapor Pressure: 1.86E-08mmHg at 25°C
• Refractive Index: 1.805
• CAS DataBase Reference: 6-methyl-11H-indolo[3,2-c]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-11H-indolo[3,2-c]quinoline(4295-28-7)
• EPA Substance Registry System: 6-methyl-11H-indolo[3,2-c]quinoline(4295-28-7)

Safety Data

• Hazardous Substances Data: 4295-28-7(Hazardous Substances Data)

Upstream product

• 32566-01-1 2-(2-aminophenyl)-1H-indole 
• 631-57-2 Acetyl cyanide 
• 754956-81-5 4-benzotriazol-1-yl-2-methyl-quinoline 
• 95-14-7 1,2,3-Benzotriazole 
• 4295-06-1 4-chloro-2-methylquinoline 
• 51336-03-9 (2-methylquinolin-4-yl)-phenylamine 
• 607-67-0 4-hydroxy-2-methylquinoline 
• 62-53-3 aniline 
• 40754-13-0 2-(1-(2-phenylhydrazineylidene)ethyl)aniline 
• 1196991-80-6 4-anilino-3-iodo-2-methylquinoline 
• 1301267-77-5 N-{2-[(2-aminophenyl)ethynyl]phenyl}acetamide 
• 52670-38-9 2-ethynylaniline 
• 58995-86-1 N-[2-(1H-indol-2-yl)phenyl]acetamide 
• 19591-17-4 o-iodoacetanilide 

Relevant articles and documents

One-pot Graebe-Ullmann synthesis of γ-carbolines under microwave irradiation

One-pot efficient and simple synthesis of γ-carboline derivatives by the Graebe-Ullmann method was conducted in a commercial microwave oven in a few minutes at a low energy level and using erlenmeyer as adequate reaction vessels. Yields are similar to those obtained by conventional heating.

A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities

A second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C-C and C-N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activities.

Indole [3,2-c] quinoline compound or its pharmaceutically acceptable salts and its preparation method and application

The invention discloses indole[3,2-c]quinoline compounds represented by formula I or pharmaceutically acceptable salts thereof, and a preparation method and an application thereof, and belongs to the technical field of the pharmaceutical chemistry. The in