59587-08-5Relevant articles and documents
A process for the preparation of N-alkyl-3,4-dialkyloxyanilines and derivatives thereof
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, (2008/06/13)
The invention provides a process for the preparation of N-alkyl-3,4-dialkyloxyanilines and derivatives thereof of the formula I wherein R1 and R2 are each identical or different lower alkyl groups or R1 and R2 taken together form a methylene bridge and R3 is H or lower alkyl comprising bromination of a compound of formula II wherein R1 and R2 are as defined above to form a compound of formula III and then reacting said compound with an aqueous alkyl amine or ammonia of the formula R3NH2 wherein R3 is as defined above to effect amination of the bromo amination of the bromo intermediate of formula III to form the compounds of formula I.