60122-51-2 Usage
Description
1H-1,7-Naphthyridin-4-one is an organic compound with a unique chemical structure that features a naphthyridine ring system. It is a key intermediate in the synthesis of various naphthyridine derivatives, which have demonstrated potential applications in the pharmaceutical industry due to their diverse biological activities.
Uses
Used in Pharmaceutical Industry:
1H-1,7-Naphthyridin-4-one is used as a key intermediate for the preparation of naphthyridine derivatives, which are valuable in the treatment of cell proliferative disorders. These derivatives have shown potential in targeting and managing various diseases characterized by abnormal cell growth, such as cancer.
In the preparation of naphthyridine derivatives, 1H-1,7-Naphthyridin-4-one serves as a building block that can be further modified and functionalized to develop compounds with specific therapeutic properties. The synthesis of these derivatives often involves various chemical reactions, such as substitution, addition, and condensation, to introduce functional groups that enhance their biological activity and selectivity towards target cells or pathways.
The development of naphthyridine-based drugs is an active area of research, as these compounds have demonstrated promising results in preclinical studies. They are being investigated for their potential to treat a wide range of cell proliferative disorders, including various types of cancer. The unique chemical structure of 1H-1,7-Naphthyridin-4-one and its derivatives allows for the fine-tuning of their properties, such as solubility, stability, and bioavailability, which are crucial factors in the design of effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 60122-51-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,1,2 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60122-51:
(7*6)+(6*0)+(5*1)+(4*2)+(3*2)+(2*5)+(1*1)=72
72 % 10 = 2
So 60122-51-2 is a valid CAS Registry Number.
60122-51-2Relevant articles and documents
ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG
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Page/Page column 96, (2015/06/03)
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.
Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones
Morgentin, Rémy,Pasquet, Georges,Boutron, Pascal,Jung, Frédéric,Lamorlette, Maryannick,Maudet, Micka?l,Plé, Patrick
, p. 2772 - 2782 (2008/09/19)
This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.
