952059-56-2

Basic information

• Product Name: 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione
• Synonyms: 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione
• CAS NO: 952059-56-2
• Molecular Weight: 264.238
• Mol File: 952059-56-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione(952059-56-2)
• EPA Substance Registry System: 2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione(952059-56-2)

Safety Data

• Hazardous Substances Data: 952059-56-2(Hazardous Substances Data)

Upstream product

• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 65600-69-3 3-aminopyridine N-oxide hydrochloride 

Downstream Products

• 5423-54-1 4-hydroxy-1,5-naphthyridine 
• 952059-55-1 2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952059-58-4 tert-butyl 2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetate 
• 952059-67-5 2-[2-methoxy-4-(1,5-naphthyridin-4-yloxy)phenyl]acetic acid 
• 16287-97-1 4-chloro-[1,7]naphthyridine 
• 7689-63-6 4-chloro-1,5-naphthyridine 
• 60122-51-2 1,7-naphthyridin-4(1H)-one 

Relevant articles and documents

Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.