60307-25-7 Usage
Description
()-1-methyl-5-oxopyrrolidine-2-acetic acid, also known as gabapentin, is a medication that is primarily used to treat epilepsy and neuropathic pain. It is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and works by inhibiting certain calcium channels in the brain, which reduces the release of neurotransmitters involved in pain signaling.
Used in Pharmaceutical Industry:
Gabapentin is used as an anticonvulsant and analgesic medication for the treatment of epilepsy and neuropathic pain. It modulates the activity of certain calcium channels in the brain, leading to a reduction in the release of neurotransmitters that are involved in pain signaling.
Used in Off-Label Treatments:
Gabapentin is also used off-label as a treatment for anxiety disorders, restless leg syndrome, and hot flashes. Its mechanism of action in these conditions is not fully understood, but it is thought to involve modulation of neurotransmitter release and inhibition of certain calcium channels in the brain.
Used in Various Dosage Forms:
Gabapentin is available in tablet, capsule, and oral solution forms, allowing for flexible dosing and administration options for patients. This makes it accessible to a wide range of individuals with different needs and preferences.
Used with Caution in Certain Patient Populations:
Due to its potential for abuse and dependence, gabapentin should be used with caution in certain patient populations, such as those with a history of substance abuse. Additionally, it may cause serious adverse reactions, including suicidal thoughts, respiratory depression, and allergic reactions, necessitating careful monitoring and consideration of individual patient risk factors.
Check Digit Verification of cas no
The CAS Registry Mumber 60307-25-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,3,0 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60307-25:
(7*6)+(6*0)+(5*3)+(4*0)+(3*7)+(2*2)+(1*5)=87
87 % 10 = 7
So 60307-25-7 is a valid CAS Registry Number.
60307-25-7Relevant articles and documents
Construction of Functionalized Azapolycyclic Architectures via Formal Amide Insertion at a Low Catalyst Loading of Copper Trifluoroacetylacetonate
Harada, Shingo,Kato, Ryosuke,Nemoto, Tetsuhiro
, p. 3123 - 3129 (2016/10/09)
A formal amide insertion reaction for the synthesis of nitrogen-bridged polycyclic frameworks with diverse functionalities was developed using a sustainable copper catalyst as an advantageous alternative to precious rhodium catalysts. The remarkable feature of this methodology is the amount of catalyst loading (0.05 mol%). The optimized reaction conditions enable access to aromatic ring-fused 8-azabicyclo[3.2.1]octane, 9-azabicyclo[3.3.1]nonane, and 6-azabicyclo[3.2.2]nonane derivatives in moderate to excellent yields. (Figure presented.).
