60771-18-8

Basic information

• Product Name: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline
• Synonyms: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline;Quinazoline, 2,4-dichloro-6-Methoxy-7-(phenylMethoxy)-
• CAS NO: 60771-18-8
• Molecular Formula: C₁₆H₁₂Cl₂N₂O₂
• Molecular Weight: 335.18468
• Mol File: 60771-18-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 447.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.54±0.30(Predicted)
• CAS DataBase Reference: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline(60771-18-8)
• EPA Substance Registry System: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline(60771-18-8)

Safety Data

• Hazardous Substances Data: 60771-18-8(Hazardous Substances Data)

Usage

General Description

The chemical 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline is a compound that belongs to the quinazoline class. It is characterized by the presence of a benzyl ether group, two chlorine atoms, and a methoxy group in its structure. 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline has potential applications in medicinal chemistry as it has been studied for its pharmacological properties, particularly its potential as an anti-cancer agent. Its structure and properties make it a valuable target for chemical synthesis and biological evaluation, with the aim of developing new drugs with improved efficacy and safety profiles for the treatment of various diseases.

Upstream product

• 1687-53-2 5-amino-2-methoxyphenol 
• 61324-40-1 3-benzyloxy-4-methoxybenzeneamine 
• 224450-48-0 tert-butyl N-(3-hydroxy-4-methoxyphenyl)carbamate 
• 60548-00-7 7-(benzyloxy)-6-methoxyquinazoline-2,4(1H,3H)-dione 
• 385785-02-4 2-amino-4-(benzyloxy)-5-methoxybenzonitrile 
• 79-22-1 methyl chloroformate 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 100-39-0 benzyl bromide 
• 52805-34-2 4-(benzyloxy)-3-methoxybenzonitrile 
• 385784-84-9 4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile 
• 56441-97-5 methyl 4-(benzyloxy)-3-methoxybenzoate 
• 61032-41-5 methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 60547-98-0 2-amino-4-benzyloxy-5-methoxybenzamide 

Downstream Products

• 219126-30-4 4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazolin-7-ol 
• 219126-29-1 7-Benzyloxy-4-(3,5-bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazoline 

Relevant articles and documents

BLOCKING TOLL-LIKE RECEPTOR 9 SIGNALING WITH SMALL MOLECULE ANTAGONIST

The present invention relates to small molecule4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defence for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation.

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COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, the disclosure contemplates inducing cells, such as adult somatic cells or cells that are not naturally pluripotent, into cells with chemically induce pluripotency. In certain embodiments, the disclosure contemplates certain compounds disclosed herein, compounds disclosed herein optionally substituted with one or more substituents, derivatives, or salts thereof, for these purposes.