6092-54-2 Usage
Description
Hexyl chloroformate is an organic compound that serves as a versatile derivatization reagent in various analytical techniques. It is known for its ability to form stable derivatives with specific analytes, enhancing their detection and analysis in complex samples.
Uses
Used in Pharmaceutical and Forensic Analysis:
Hexyl chloroformate is used as a derivatization reagent for the determination of specific compounds in urine and urinary sediments. This application is crucial in pharmaceutical and forensic analysis for detecting and monitoring drug metabolites or other biomarkers.
Used in Solid-Phase Microextraction and Fast GC-MS Analysis:
In this application industry, hexyl chloroformate is used as a derivatization reagent for the determination of sarcosine and N-ethylglycine in urine and urinary sediments. The derivatization process improves the volatility and stability of these analytes, allowing for more accurate and sensitive detection using solid-phase microextraction and fast gas chromatography-mass spectrometry (GC-MS) techniques.
Used in GC-Quadrupole Ion Trap Mass Spectrometry:
Hexyl chloroformate is also used as a derivatization reagent in the determination of benzoylecgonine in urine by gas chromatography with a quadrupole ion trap mass spectrometer. This technique benefits from the improved properties of the derivatized analyte, leading to enhanced detection and quantification of the target compound in complex biological samples.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 6092-54-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,9 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6092-54:
(6*6)+(5*0)+(4*9)+(3*2)+(2*5)+(1*4)=92
92 % 10 = 2
So 6092-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H13ClO2/c1-2-3-4-5-6-10-7(8)9/h2-6H2,1H3
6092-54-2Relevant articles and documents
Photo-on-Demand Synthesis of Chloroformates with a Chloroform Solution Containing an Alcohol and Its One-Pot Conversion to Carbonates and Carbamates
Liang, Fengying,Suzuki, Yuto,Tsuda, Akihiko,Yanai, Masaki
supporting information, (2020/04/21)
Chloroformates are key reagents for synthesizing carbonates and carbamates. The present study reports a novel photo-on-demand in situ synthesis of chloroformates with a CHCl3 solution containing a primary alkyl alcohol. It further allowed the one-pot synthesis of carbonates and carbamates through subsequent addition of alcohols or amines, respectively.
Neuraminic acid inhibitor prodrug composition and use thereof
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Paragraph 0109; 0112-0114, (2016/10/20)
Provided are a compound as represented by formula Ia, or pharmaceutically acceptable salt, solvate, polymorph, enantiomer or racemic mixture thereof. As a neuraminidase inhibitor prodrug, the compound can improve the half-life in vivo of the neuraminidase inhibitor. Also provided are a preparation method of the compound, pharmaceutical composition containing the compound, and uses of the compound and the pharmaceutical composition in the preparation of neuraminidase inhibitor drugs for treating related diseases.
Method for the preparation of aliphatic chloroformates
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Page/Page column 7-8, (2008/06/13)
A method for preparing an aliphatic chloroformate comprising, introducing a mixture of at least one aliphatic hydroxyl compound, phosgene, at least one solvent, and optionally at least one organic base into a flow reactor to obtain a unidirectional flowing reaction mixture. The at least one aliphatic hydroxyl compound comprises at least one aliphatic hydroxyl group. The unidirectional flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aliphatic chloroformate.