610-67-3

Basic information

• Product Name: 2-NITROPHENETOLE
• Synonyms: 1-ethoxy-2-nitro-benzen;1-ETHOXY-2-NITROBENZENE;O-NITROPHENETOLE;Nitrophenetole;ORTHO-NITROPHENETOLE;2-Ethoxynitrobenzol;2-Ethoxynitrobenzene;2-Nitrophenylethylether
• CAS NO: 610-67-3
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 210-232-6
• Product Categories: Intermediates of Dyes and Pigments;Phenetole
• Mol File: 610-67-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 1.1°C
• Boiling Point: 275 °C
• Flash Point: 4 °C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 0.0119mmHg at 25°C
• Refractive Index: 1.5410 to 1.5440
• CAS DataBase Reference: 2-NITROPHENETOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITROPHENETOLE(610-67-3)
• EPA Substance Registry System: 2-NITROPHENETOLE(610-67-3)

Safety Data

• Hazard Codes: Xi
• RTECS: SI7942000
• Hazardous Substances Data: 610-67-3(Hazardous Substances Data)

Usage

General Description

2-Nitrophenetole, also known as o-Nitrophenetole, is an organic compound and a member of the nitrophenols family. It is a colorless to yellow liquid with a faint, sweet, floral odor. The chemical is mainly used in the synthesis of other organic compounds and as an intermediate in the production of pharmaceuticals, dyes, and perfumes. It is also used as a flavoring agent in the food industry. However, 2-nitrophenetole is considered to be hazardous and can cause irritation to the eyes, skin, and respiratory system upon exposure. It is important to handle this chemical with caution and use appropriate protective equipment during its handling and storage.

InChI:InChI=1/C8H9NO3/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 824-38-4 potassium 2-nitrophenoxide 
• 75-00-3 chloroethane 
• 824-39-5 sodium o-nitrophenate 
• 91-23-6 2-Nitroanisole 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 86255-27-8 silver(I) 2-nitrophenoxide 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 88-73-3 2-Chloronitrobenzene 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 56-23-5 tetrachloromethane 
• 6786-32-9 benzoyl nitrate 
• 103-73-1 Phenetole 

Downstream Products

• 13620-57-0 2,2'-dimethoxyazoxybenzene 
• 130728-51-7 bis-(4-ethoxy-3-nitro-phenyl)-methane 
• 1033-71-2 2,2'-diethoxyhydrazobenzene 
• 91-23-6 2-Nitroanisole 
• 613-43-4 2,2'-diethoxyazobenzene 
• 62167-96-8 bis-(2-ethoxy-phenyl)-diazene-N-oxide 
• 94-70-2 ortho-phenitidine 
• 139444-58-9 3-ethoxy-4-amino-phenol 
• 860742-51-4 N-(4-chloro-2-ethoxyphenyl)acetamide 
• 23169-51-9 1-Aethoxy-phenazin 
• 127285-31-8 2-ethoxy-4-methoxy-aniline 
• 90-04-0 2-methoxy-phenylamine 
• 344296-52-2 2-ethoxy-6-methoxyaniline 
• 95-21-6 2-methyl-1,3-benzoxazole 

Relevant articles and documents

Production method of o/p-nitrophenetole

The invention discloses a production method of o/p-nitrophenetole, which comprises the following steps: (1) adding o/p-nitrochlorobenzene and ethanol into a four-neck flask provided with a heating reflux matching device, then adding N-methylmorpholine, co

Aryl Ether Syntheses via Aromatic Substitution Proceeding under Mild Conditions

In this study, mild conditions for aromatic substitutions during the syntheses of aryl ethers were developed. In the reaction conditions, the choices of solvent, base, and the sequence for the addition of the reagents proved important. A wide variety of alcohols were used directly as nucleophiles and smoothly reacted with aryl chlorides that possessed either a nitro or a cyano group at either the ortho- or para-position. Controlled experiments we performed suggested that the reaction underwent a charge-transfer process mediated by a combination of DMF and tert-BuOK.

Ipso-Nitrosation of arylboronic acids with chlorotrimethylsilane and sodium nitrite

Nitroso compounds are versatile reagents in synthetic organic chemistry. Herein, we disclose a feasible protocol for the ipso-nitrosation of aryl boronic acids using chlorotrimethylsilane-sodium nitrite unison as nitrosation reagent system.