6149-33-3Relevant articles and documents
pH-sensitive 4,(4-Nitrophenoxy)benzeneamine) derived azo dye: X-ray crystallographic, DFT and electrochemical studies
Akhter, Zareen,Perveen, Fouzia,Qamar, Samina,Yousuf, Sammer
, (2020)
A novel nitro terminated azo dye, (E)-3-((4-(4-nitrophenoxy)phenyl)diazenyl)-[1,1′-biphenyl]-4-ol (1), was produced by coupling biphenyl-4-ol with 4,(4-Nitrophenoxy)benzeneamine) and was characterized by various spectroscopic and XRD technique. The chemical structure of the compound (1) has a nitro terminal as an electron-withdrawing moiety (A), a biphenyl ring of coupling part as a proton-donating unit (D), and both groups are linked by an azo group connector. The stimulating pH-controlled absorption behavior of chemosensor was investigated using UV/VIS spectroscopic technique. It was observed that synthesized dye (1) has high sensitivity in pH range from 7.9 to 10.46 and could be applied as a selective ‘naked-eye’ colorimetric sensor for H+ ion concentration, as it exhibited a very strong hyperchromic shift in the absorption band from 399 nm to 521 nm with a significant color change from yellow to red. The sensitivity of chemosensor was observed to be fully reversible and rapid which enhance its chances of practical implicitly. Further, DFT simulations were performed using ADF-Modeling suite 2019, to get an idea of relevance with experiments. Additionally, redox behavior of the (1) dye was also investigated by employing cyclic voltammetry using 0.1M TBAP as supporting electrolyte. Cis–Trans conformational changes were analyzed to investigate the photoisomerization ability of the synthesized dye.
Quinoline or quinazoline compound as well as preparation method and application thereof
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Paragraph 0064; 0165; 0167, (2019/01/23)
The invention relates to quinoline or quinazoline compound as well as a preparation process and application thereof. The structural formula is shown in the description. The quinoline or quinazoline compound can inhibit the activity of PFKFB3 in tumor cells, effectively block activation of key enzymes during a glycolysis process, and inhibit energy supply for tumor cells.
Synthesis of new 4[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones and their evaluation as anthelmintics
Namratha,Bilehal, Dinesh,Shyamkumar,Gaonkar, Santosh L.
, p. 1885 - 1897 (2016/03/16)
A library of novel 4-[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4-triazole-3-thiones containing different substituents at the 5-position is synthesized. The mechanochemical treatment is followed to synthesize target compounds 8 (a-p), and the yields are compared by both the grinding method and the conventional method. The structure of the intermediate, isothiocyanato-4-(4-nitrophenoxy)benzene 6, is analyzed by single crystal X-ray studies. The title compounds are characterized by spectral and elemental analyses and further evaluated for their efficacy as anthelmintics in vitro. Compounds 8c, 8j, 8k, 8l, and 8m exhibit significant anthelmintic activity.