616-31-9

Basic information

• Product Name: pentane-3-thiol
• Synonyms: pentane-3-thiol;Pentan-3-thiol
• CAS NO: 616-31-9
• Molecular Formula: C₅H₁₂S
• Molecular Weight: 104.21378
• EINECS: 210-476-3
• Mol File: 616-31-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: -110.8°C
• Boiling Point: 113.9°C
• Flash Point: 15°C
• Appearance: /liquid
• Density: 0.837
• Vapor Pressure: 35mmHg at 25°C
• Refractive Index: 1.4421
• CAS DataBase Reference: pentane-3-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: pentane-3-thiol(616-31-9)
• EPA Substance Registry System: pentane-3-thiol(616-31-9)

Safety Data

• Hazardous Substances Data: 616-31-9(Hazardous Substances Data)

Usage

General Description

Pentane-3-thiol is a chemical compound with the molecular formula C5H12S. It is a colorless liquid with a foul, garlic-like odor, and is commonly used in organic synthesis, such as in the preparation of mercaptans. Pentane-3-thiol is also used as a reagent in the manufacturing of pharmaceuticals, agrochemicals, and flavoring compounds. Its strong odor makes it useful as a warning odorant in natural gas, which helps detect leaks, and it is also used to impart an odor to natural gas and propane so that leaks can be quickly detected. Additionally, it can also be found in trace amounts in some food products, beverages, and natural sources, such as garlic and onions. Overall, pentane-3-thiol has a variety of uses in different industries due to its unique odor and chemical properties.

InChI:InChI=1/C5H12S/c1-3-5(6)4-2/h5-6H,3-4H2,1-2H3

Upstream product

• 584-02-1 2-pentanol 
• 99868-42-5 bis-(1-ethyl-propyl)-disulfide 
• 616-20-6 3-chloropentane 
• 17356-08-0 thiourea 
• 1809-10-5 3-bromopentane 
• 7783-06-4 hydrogen sulfide 
• 96511-93-2 S-(1-ethyl-propyl)-isothiourea 
• 109-67-1 1-penten 
• 3221-15-6 2-(chloromethyl)thiirane 
• 917-54-4 methyllithium 
• 441061-03-6 3-acetylthiopentane 
• 950-25-4 toluene-4-sulfonic acid 1-ethyl-propyl ester 

Downstream Products

• 626-97-1 pentamide 
• 99842-02-1 (1-ethyl-propyl)-(2,4-dinitro-phenyl)-sulfide 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. Compounds of the disclosure have activity as dual modulators of Janus kinase (JAK), alone, or in combination with one or more of an additional mechanism, including a tyrosine kinase, such as TrkA or Syk, and PDE4, and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK and PDE4 by administering a compound herein described.

Reactions of 2-(α-Haloalkyl)thiiranes with nucleophilic reagents: V.* Reactions of 2-(α-chloroalkyl)thiiranes with organolithium compounds

2-(α-Haloalkyl)thiiranes reacted with methyl-, butyl-, and phenyllithium to give the corresponding allyl sulfides. The reactions of diastereoisomeric erythro-and threo-2-(1-chloroethyl)thiiranes with phenyllithium were stereospecific, and they afforded (E)-and (Z)-1-phenylsulfanylbut-2-enes, respectively. 3-Chloromethyl-2,2- dimethylthiirane and phenyllithium gave rise to a mixture of 3-methyl-3-phenylsulfanylbut-1-ene and 3-methyl-1-phenylsulfanylbut-2-ene. The reactions of 2-chloromethylthiiranes with phenyllithium and methyllithium in the presence of a catalytic amount of copper(I) iodide (10 mol %) led to the formation of substituted thiiranes as the major products. Mechanisms of the observed transformations are discussed. Pleiades Publishing, Ltd., 2010.

N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION

The invention relates to compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic application.