621685-57-2Relevant articles and documents
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors
Dyckman, Alaric J.,Li, Tianle,Pitt, Sidney,Zhang, Rosemary,Shen, Ding Ren,McIntyre, Kim W.,Gillooly, Kathleen M.,Shuster, David J.,Doweyko, Arthur M.,Sack, John S.,Kish, Kevin,Kiefer, Susan E.,Newitt, John A.,Zhang, Hongjian,Marathe, Punit H.,McKinnon, Murray,Barrish, Joel C.,Dodd, John H.,Schieven, Gary L.,Leftheris, Katerina
, p. 4633 - 4637 (2011/09/15)
Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models o
