624-80-6Relevant articles and documents
Heteroaromatic moieties in the sphingosine backbone of α- Galactosylceramides for noncovalent interactions with CD1d
Kim, Yongju,Kim, Jonghoon,Oh, Keunhee,Lee, Dong-Sup,Park, Seung Bum
supporting information; experimental part, p. 151 - 154 (2012/04/04)
A series of α-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of α-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.
Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
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Page 8, (2008/06/13)
The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives. The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.
Oxidation of aliphatic amides by N-chlorobenzenesulfonamide in acid medium catalyzed by ruthenium(III): A kinetic and mechanistic study
Puttaswamy,Jagadeesha,Ramalingaiah, Hulivana
, p. 426 - 432 (2007/10/03)
The kinetics of the ruthenium(III)-catalyzed oxidation of urea and substituted ureas, namely, methylurea, ethylurea and propylurea by sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) in HCI medium have been studied at 30°. The reaction rate shows a first order dependence each on [CAB], [amide] and [RuIII] and fractional order on [H+]. Additions of halide ions and the reaction product of CAB (benzenesulfonamide) and the variation of ionic strength and dielectric constant of the medium do not have any significant effect on the reaction rate. Activation parameters have been evaluated. The rate increases in D2O medium. Proton inventory studies were made in H2O-D2O mixtures for both the amides. A Taft linear free energy relationship is observed for the reaction with ρ* = -0.88 and -3.20 and δ = -0.33, indicating that electron-donating groups enhance the rate. An isokinetic relation is observed with β = 372 K confirmed by the Exner criterion. The protonation constant of monochloramine-B has been evaluated to be 8.6. A mechanism consistent with the observed kinetic data has been proposed. The rate of oxidation increases in the order: propylurea > ethylurea > methylurea > urea.