63324-49-2 Usage
General Description
H-D-LEU-PNA is a chemical compound that consists of the amino acid leucine bound to a peptide nucleic acid (PNA) backbone. H-D-LEU-PNA is commonly used in research and pharmaceutical applications for its ability to specifically target and bind to complementary nucleic acid sequences through base pairing interactions. By incorporating leucine into the PNA backbone, H-D-LEU-PNA enhances the stability and binding affinity of the compound, allowing for more efficient and specific targeting of DNA or RNA sequences. This unique chemical structure makes H-D-LEU-PNA a valuable tool for studying gene expression, developing diagnostic probes, and designing therapeutic interventions for various genetic diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 63324-49-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,2 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 63324-49:
(7*6)+(6*3)+(5*3)+(4*2)+(3*4)+(2*4)+(1*9)=112
112 % 10 = 2
So 63324-49-2 is a valid CAS Registry Number.
63324-49-2Relevant articles and documents
Kinetic study on conformational effect in hydrolysis of p-nitroanilides catalyzed by α-chymotrypsin
Kawai, Yasushi,Matsuo, Takashi,Ohno, Atsuyoshi
, p. 887 - 891 (2007/10/03)
Effects of medium viscosity on kinetics for the hydrolysis of p-nitroanilides of certain amino acid derivatives catalyzed by α-chymotrypsin have been investigated. Observed data indicate that the overall rate constant, kcat, is hardly affected by the medium viscosity in all the substrates employed and equals the rate constant at the acylation step, k2, in the measured range of viscosity. By comparison with the data on p-nitrophenyl ester substrates reported previously, it is concluded that the formation of the tetrahedral intermediate in the course of the acylation of the enzyme is influenced by conformational change of the enzyme, whereas the breakdown of the intermediate is almost free from conformational effects.
Synthesis of chromogenic substrates specific for human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE).
Okada,Tsuda,Hirata,Nagamatsu,Okamoto
, p. 4060 - 4068 (2007/10/02)
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