63521-15-3

Basic information

• Product Name: Cefazedone sodium salt
• Synonyms: sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Cefazedone, sodium salt;Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-trans)-;Nsc304118;Refosporin sodium salt
• CAS NO: 63521-15-3
• Molecular Formula: C₁₈H₁₄Cl₂N₅O₅S₃*Na
• Molecular Weight: 570.42503
• EINECS: 264-293-9
• Mol File: 63521-15-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.78g/cm3
• Refractive Index: 1.76
• CAS DataBase Reference: Cefazedone sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cefazedone sodium salt(63521-15-3)
• EPA Substance Registry System: Cefazedone sodium salt(63521-15-3)

Safety Data

• Hazardous Substances Data: 63521-15-3(Hazardous Substances Data)

Usage

Therapeutic Function

Antibiotic

InChI:InChI=1/C18H15Cl2N5O5S3/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30)

Upstream product

• 63760-59-8 7-aminocephalosporanic acid 
• 107447-96-1 7-phenylacetylamino-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester 
• 30246-33-4 (6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 70149-51-8 3,5-Dichlor-4-pyridon-1-yl-ethylacetat 
• 957-68-6 7-Aminocephalosporanic acid 
• 56187-47-4 cefazedone 

Relevant articles and documents

CEFAZEDONE SODIUM NEW CRYSTAL FORMS AND METHOD FOR MANUFACTURING THE SAME

The present invention relates to a novel crystal form of cepovidone sodium and a process for producing the same. , It will be described below. The X-ray powder diffraction pattern according to the 5.108 ±0.2 ° present 10.244 ±0.2 ° invention 12.355 ±0.2 ° has a characteristic diffraction 13.383 ±0.2 ° peak 16.124 ±0.2 ° at 19.180 ±0.2 ° 20.740 ±0.2 °, 23.012 ±0.2 ° 2 θ and, in each section of. (by machine translation)

New crystal form of cefazedone sodium salt and preparation method of new crystal form

The invention relates to a new crystal form of cefazedone sodium salt and a preparation method of the new crystal form, in particular to a crystal form of cefazedone sodium salt. The X-ray powder diffraction pattern of the crystal form of cefazedone sodium salt has characteristic diffraction peaks at the following 2theta angles: 5.108+/-0.2 degrees, 10.244+/-0.2 degrees, 12.355+/-0.2 degrees, 13.383+/-0.2 degrees, 16.124+/-0.2 degrees, 19.180+/-0.2 degrees, 20.740+/-0.2 degrees and 23.012+/-0 .2 degrees.

Preparation technology of cefazedone sodium

The invention belongs to the technical field of medicine, and discloses a preparation technology of cefazedone sodium. 3,5-dichloropyridone acetic acid and pivaloyl chloride are taken as the raw materials to synthesize mixed acid anhydrides; and then cefazedone sodium is obtained after salt forming reactions between mixed acid anhydrides and an intermediate prepared from 7-aminocephalosporanic acid and thiol tetrazole. A mixed solvent is used in 3-substitution, the reaction becomes more stable and softer, the byproducts are reduced; in acylation reactions, mixed acid anhydrides are used, the activity is high, 7-acylation reactions are promoted, and thus the yield and purity of cefazedone sodium are high.