63762-79-8

Basic information

• Product Name: 2-FLUORO-5-METHYLPHENOL
• Synonyms: 2-FLUORO-5-METHYLPHENOL;6-FLUORO-M-CRESOL;BUTTPARK 13\03-06;Fluoromethylphenol1;6-Fluoro-m-methylphenol;2-Fluoro-5-methylphenol 98%;2-Fluoro-5-methylphenol98%;4-Fluoro-3-hydroxytoluene
• CAS NO: 63762-79-8
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• EINECS: 264-514-9
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Fluorinated benzene series;NULL;Fluorine series
• Mol File: 63762-79-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 32 °C
• Boiling Point: 173 °C(lit.)
• Flash Point: 153 °F
• Appearance: COLORLESS TO YELLOW LIQUID
• Density: 1.155 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00138mmHg at 25°C
• Refractive Index: n20/D 1.511(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.82±0.10(Predicted)
• BRN: 2433017
• CAS DataBase Reference: 2-FLUORO-5-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-METHYLPHENOL(63762-79-8)
• EPA Substance Registry System: 2-FLUORO-5-METHYLPHENOL(63762-79-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-21/22
• Safety Statements: 26-36-36/37/39
• RIDADR: 2922
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 63762-79-8(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow liquid

Uses

2-Fluoro-5-methylphenol may be employed as additive in various alkyne metatheses.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014

General Description

2-Fluoro-5-methylphenol is a fluorinated aromatic compound.

InChI:InChI=1/C11H13F3N2/c12-11(13,14)9-3-1-2-4-10(9)16-7-5-15-6-8-16/h1-4,15H,5-8H2

Upstream product

• 452-84-6 3-amino-4-fluorotoluene 
• 108-39-4 3-methyl-phenol 
• 39538-68-6 2-methoxy-4-methylaniline 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 95-48-7 ortho-cresol 

Downstream Products

• 63762-80-1 2-nitro-4-fluoro-5-hydroxy-toluene 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 320351-01-7 3-benzoyloxy-4-fluorotoluene 
• 550400-07-2 4-bromo-2-fluoro-5-methylphenol 
• 847832-97-7 2-[1-(2-chloro-ethyl)-2-methyl-propoxy]-1-fluoro-4-methyl-benzene 
• 1443354-44-6 C₁₃H₁₇FO₃ 
• 870779-62-7 benzoic acid 5-{[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl}-2-fluorophenyl ester 
• 537683-41-3 4-[(4-Fluoro-3-hydroxy-benzyl)-[1,2,4]triazol-4-yl-amino]-benzonitrile 
• 320351-00-6 α-bromo-3-benzyloxy-4-fluorotoluene 
• 1026905-54-3 4-methoxy-5-allyl-6-methyl-3-fluoro-bromobenzene 
• 320350-99-0 7-(3-benzoyloxy-4-fluorobenzyloxy)-3,4-dimethyl-2H-chromen-2-one 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 

Relevant articles and documents

Phenol compound ortho-position direct fluorination method

The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.

Synthesis and Dopamine Receptor Affinities of 2-(4-fluoro-3-hydroxyphenyl)ethylamine and N-Substituted Derivatives

The synthesis of 2-(4-fluoro-3-hydroxyphenyl)ethylamine (26) and of some N,N-dialkyl derivatives (27-30) starting from 4-fluoro-3-hydroxytoluene and their in vitro binding affinities for dopamine (DA) receptor are reported.The amine 26 can be regarded as

DIRECT FLUORINATION OF PHENOL AND CRESOLS

A study has been made of the reaction of phenol with elemental fluorine using a variety of solvents and reaction temperatures.Yields of o- and p-fluorophenol were obtained as high as 85percent.The isomer ratio changed drastically between phenol conversions of 10percent and 56percent.The o-isomer changed to unidentified polymeric substances at higher conversion, but it might also be assumed that interconversion of some isomers is occuring.The three cresols have also been succesfully fluorinated with elemental fluorine. p-Cresol gave some expected 2-fluoroderivative but also formed a fluorocyclohexadienyl ketone.