63762-80-1

Basic information

• Product Name: 2-Fluoro-5-methyl-4-nitrophenol
• Synonyms: 2-Fluoro-5-methyl-4-nitrophenol
• CAS NO: 63762-80-1
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.1258432
• Mol File: 63762-80-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 288.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.94±0.24(Predicted)
• CAS DataBase Reference: 2-Fluoro-5-methyl-4-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-methyl-4-nitrophenol(63762-80-1)
• EPA Substance Registry System: 2-Fluoro-5-methyl-4-nitrophenol(63762-80-1)

Safety Data

• Hazardous Substances Data: 63762-80-1(Hazardous Substances Data)

Usage

Synthesis

Added 2-fluoro-5-methylphenol (0.200 g, 1.59 mmol) to a 5 mL flask followed by AcOH (0.40 mL) and H2SO4 (0.058 mL) at 0 ?C (ice-salt bath). Then sodium nitrite (0.29 mL of 5.5 M in water) was slowly added to the reaction to give a burnt orange color. The reaction was stirred for 30 min on the ice bath.?Poured reaction over ice and then filtered off a light orange solid. Warmed 20% nitric Acid in water (5 mL) to 45 ?C then added the orange solid in portions while stirring. The reaction was stirred for twenty min then diluted with water and cooled. The light orange solid was filtered off to give 2-fluoro-5-methyl- 4-nitrophenol as a light orange solid (0.124g, 46% yield). 1H NMR (500 MHz, DMSO-d6) δ 13.86 (s, 1H), 7.42 (d, J = 11.6 Hz, 1H), 6.47 (dq, J = 8.2, 1.3 Hz, 1H), 2.23 (d, J = 1.3 Hz, 3H).

Upstream product

• 63762-79-8 2-fluoro-5-methylphenol 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 39538-68-6 2-methoxy-4-methylaniline 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 367-12-4 2-fluorophenol 

Downstream Products

• 63762-81-2 1-fluoro-2-methoxy-4-methyl-5-nitrobenzene 
• 63762-82-3 [(E)-2-(4-Fluoro-5-methoxy-2-nitro-phenyl)-vinyl]-dimethyl-amine 
• 1263299-46-2 5-fluoro-4-methoxy-2-methylaniline 

Relevant articles and documents

INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE

Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Structural determinants influencing the potency and selectivity of indazole-paroxetine hybrid G protein-coupled receptor kinase 2 inhibitors

G protein-coupled receptor kinases (GRKs) phosphorylate activated receptors to promote arrestin binding, decoupling from heterotrimeric G proteins, and internalization. GRK2 and GRK5 are overexpressed in the failing heart and thus have become therapeutic

COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

Provided are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also provided are pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.