6399-81-1 Usage
Description
Triphenylphosphine hydrobromide, also known as TPP-HBr, is a white to light beige crystalline powder or chunks that is the hydrobromide salt of triphenylphosphine. It is a versatile reagent in organic chemistry, known for its unique chemical properties and various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Triphenylphosphine hydrobromide is used as a substrate donor analog of UDP-sugars for glycosyltransferases, which are essential enzymes in the biosynthesis of various carbohydrates. This application is particularly relevant in the preparation of uridine derivatives, playing a crucial role in the development of new drugs and therapies.
Used in Chemical Synthesis:
Triphenylphosphine hydrobromide serves as a mild source of anhydrous HBr, acting as a catalyst for the formation of THP ethers from tertiary alcohols. This process is vital in the synthesis of various organic compounds and contributes to the development of new chemical products.
Used in Surface Active Agents and Antibacterial Compounds:
Triphenylphosphine hydrobromide is utilized in the preparation of tensioactive and antibacterial deoxyglycoside compounds. These compounds have significant applications in the formulation of detergents, cleaning agents, and antimicrobial products, contributing to improved hygiene and sanitation.
Used in Catalyst Preparation:
In the field of catalysis, triphenylphosphine hydrobromide is employed in the preparation of phosphonium salts, which are essential catalysts for various chemical reactions. These catalysts play a vital role in enhancing the efficiency and selectivity of numerous industrial processes, leading to the production of high-quality products with reduced environmental impact.
Check Digit Verification of cas no
The CAS Registry Mumber 6399-81-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,9 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6399-81:
(6*6)+(5*3)+(4*9)+(3*9)+(2*8)+(1*1)=131
131 % 10 = 1
So 6399-81-1 is a valid CAS Registry Number.
InChI:InChI=1/C18H15P.BrH/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;/h1-15H;1H
6399-81-1Relevant articles and documents
A convenient and economic way to produce anhydrous hydrogen bromide
Wang,Schlosser
, p. 479 - 482 (1994)
Bromide promoted decomposition of tert-butyl bromide in the presence of triphenylphosphine gives, besides isobutene, hydrogen(triphenyl)phosphonium bromide. When heated to approximately 150°C in the presence of xylene, the latter salt liberates hydrogen bromide which may then be trapped in an aprotic solvent such as diethyl ether.
Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors
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Paragraph 0317, (2018/07/05)
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria and in particular in Staphylococcus aureus. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections of Staphylococcus bacteria and in particular of Staphylococcus aureus. Methods for treating such bacterial infections are provided.
Enantioselective Trifluoromethylthiolating Lactonization Catalyzed by an Indane-Based Chiral Sulfide
Liu, Xiang,An, Rui,Zhang, Xuelin,Luo, Jie,Zhao, Xiaodan
supporting information, p. 5846 - 5850 (2016/05/09)
Enantioselective trifluoromethylthiolation, especially of alkenes, is a challenging task. In this work, we have developed an efficient approach for enantioselective trifluoromethylthiolating lactonization by designing an indane-based bifunctional chiral sulfide catalyst and a shelf-stable electrophilic SCF3 reagent. The desired products were formed with diastereoselectivities of >99:1 and good to excellent enantioselectivities. The transformation represents the first enantioselective trifluoromethylthiolation of alkenes and the first enantioselective trifluoromethylthiolation that is enabled by a catalyst with a Lewis basic sulfur center.
