642-28-4

Basic information

• Product Name: naphthalen-1-yl(phenyl)methanol
• Synonyms: 1-Naphthalenemethanol, .alpha.-phenyl-; 1-naphthalenemethanol, alpha-phenyl-; 1-Naphthyl(phenyl)methanol
• CAS NO: 642-28-4
• Molecular Formula: C₁₇H₁₄O
• Molecular Weight: 234.2925
• Mol File: 642-28-4.mol
• Article Data: 100

Chemical Properties

• Boiling Point: 415.9°C at 760 mmHg
• Flash Point: 181°C
• Density: 1.164g/cm³
• Vapor Pressure: 1.16E-07mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: naphthalen-1-yl(phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: naphthalen-1-yl(phenyl)methanol(642-28-4)
• EPA Substance Registry System: naphthalen-1-yl(phenyl)methanol(642-28-4)

Safety Data

• Hazardous Substances Data: 642-28-4(Hazardous Substances Data)

Upstream product

• 642-29-5 1-benzoylnaphthalene 
• 810-55-9 1,2-di-[1]naphthyl-1,2-diphenyl-ethane-1,2-diol 
• 100-52-7 benzaldehyde 
• 703-55-9 1-naphthylmagnesiumbromide 
• 927-77-5 n-propylmagnesium bromide 
• 71-43-2 benzene 
• 78199-49-2 1-(α-Acetoxybenzyl)naphthalene 
• 66-77-3 1-naphthaldehyde 
• 16508-18-2 Benzoyl-methyl-<1>naphthyl-phenyl-silan 
• 98-80-6 phenylboronic acid 
• 64-17-5 ethanol 
• 6245-96-1 α-naphthylmethyl phenyl ether 
• 7664-93-9 sulfuric acid 
• 99802-63-8 2-hydroxy-2-(naphthalen-1-yl)-1,2-diphenylethanone 

Downstream Products

• 642-29-5 1-benzoylnaphthalene 
• 611-45-0 1-Benzyl-naphthalene 
• 93259-74-6 1-(α-chlorobenzyl)naphthalene 
• 199111-37-0 α-naphthylbenzylbromide 
• 103512-58-9 bis-([1]naphthyl-phenyl-methyl)-ether 
• 136908-19-5 1-(Benzhydryloxy-phenyl-methyl)-naphthalene 
• 321-38-0 1-Fluoronaphthalene 
• 147022-03-5 1-(Naphthalen-1-yl-phenyl-methyl)-1H-imidazole 
• 134295-68-4 (R)-1-Methoxy-1-(α-naphthyl)-1-phenylmethane 
• 100-52-7 benzaldehyde 
• 5267-53-8 α-Phenyl-1-naphthalinmethanamin-Hydrochlorid 
• 642-28-4 (R)-naphthalen-1-yl-phenyl-methanol 
• 1517-61-9 (S)-1-naphthyl(phenyl)methanol 

Relevant articles and documents

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

Chiral electron-rich PNP ligand with a phospholane motif: Structural features and application in asymmetric hydrogenation

Despite the remarkable reactivity that was achieved by a series of transition-metal catalysts with a PNP type ligand, the electron-rich chiral PNP ligands have still been rarely reported because of the difficulties in synthesis and the nature of air-sensitivity. Herein, we report a novel chiral PNP ligand (Heng-PNP) with both a rigid backbone and a bulky tert-butyl group on the phospholane motif. We successfully obtained its divalent iron complex. The chiral environment of its Ir(III) complex was also discussed with quadrant analysis. This tridentate ligand was applied in iridium-catalyzed asymmetric hydrogenation of challenging diaryl ketones: up to 98% ee and 500 TON are achieved. Computational study showed that the twist of conjugate aryl group in the substrate (induced by the special chiral pocket of Ir/Heng-PNP complex) leads to the energy difference in the enantiodetermining step.