64506-49-6 Usage
Pharmacological action
Sofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.
Figure 1 Structural formula for sofalcone
Pharmacokinetics
This product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.
Description
Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle
of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a
strengthening of the mucosal barrier through an increase in blood flow and
stimulation of the synthesis of sulfated mucopolysaccharides.
Originator
Japan (Japan)
Uses
Different sources of media describe the Uses of 64506-49-6 differently. You can refer to the following data:
1. Sofalcone is a substituted chalcone with anti-ulcer activity.
2. Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]
Check Digit Verification of cas no
The CAS Registry Mumber 64506-49-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,5,0 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64506-49:
(7*6)+(6*4)+(5*5)+(4*0)+(3*6)+(2*4)+(1*9)=126
126 % 10 = 6
So 64506-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+
64506-49-6Relevant articles and documents
2-(Carboxymethoxy)-chalcones
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, (2008/06/13)
Novel 2'-(carboxymethoxy)-chalcones of the formula STR1 wherein one or two of X1, X2 and X3 are 3-methyl-2-butenyloxy and the other or others are hydrogen, possess excellent antigastric and anti-duodenal ulcer activities,
