65136-50-7Relevant articles and documents
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Montanari, Serena,Mahmoud, Ali Mokhtar,Pruccoli, Letizia,Rabbito, Alessandro,Naldi, Marina,Petralla, Sabrina,Moraleda, Ignacio,Bartolini, Manuela,Monti, Barbara,Iriepa, Isabel,Belluti, Federica,Gobbi, Silvia,Di Marzo, Vincenzo,Bisi, Alessandra,Tarozzi, Andrea,Ligresti, Alessia,Rampa, Angela
, p. 243 - 258 (2019/06/14)
To address the multifactorial nature of Alzheimer's Disease (AD), a multi-target-directed ligand approach was herein developed. As a follow-up of our previous studies, a small library of newly designed 2-arylbenzofuran derivatives was evaluated towards ch
Piperidine nucleophilic substitution without solvent: An efficient synthesis of raloxifene
Yang, Yewei,Zhang, Tao,Huang, Wenhai,Shen, Zhenrong
, p. 3271 - 3276 (2015/10/06)
Mild and high-yielding synthesis is described for raloxifene via piperdine nucleophilic substitution of a new raloxifene intermediate 3-aroyl-2-aryl-substituted benzo[b]thiophenes, which is obtained by acylation of para-substituted benzoyl chlorides and 2-arylbenzo[b]thiophenes. The key step is solvent free and offers valuable advantages, such as low cost, and is suitable for industrial production.
Benzothiophenes and related compounds as estrogen agonists
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Page/Page column 42, (2010/02/07)
The invention is a compound of Formula (I): wherein R is —OH, R1is —OH, R2is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt of a compound having Formula (1), or a pharmaceutical composition comprising a compou