654-11-5

Basic information

• Product Name: 3,5-Difluoro-4-methoxybenzaldehyde
• Synonyms: 3,5-DIFLUORO-4-METHOXYBENZALDEHYDE;3,5-Difluoro-4-methoxybenzaldehyde 99%;3,5-Difluoro-4-methoxybenzaldehyde99%;3,5-difluoro-4-methoxybenzaldehdye;2,6-Difluoro-4-formylanisole, 3,5-Difluoro-p-anisaldehyde
• CAS NO: 654-11-5
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 654-11-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 38-40°C
• Boiling Point: 246.642 °C at 760 mmHg
• Flash Point: 100.025 °C
• Appearance: /
• Density: 1.289 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3,5-Difluoro-4-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoro-4-methoxybenzaldehyde(654-11-5)
• EPA Substance Registry System: 3,5-Difluoro-4-methoxybenzaldehyde(654-11-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 654-11-5(Hazardous Substances Data)

Usage

General Description

3,5-Difluoro-4-methoxybenzaldehyde is a chemical compound with the chemical formula C8H6F2O2. Belonging to the class of organic compounds known as benzaldehydes, it is characterized by a benzene ring core carrying an aldehyde group. This particular compound also features two fluorine substitutions at the 3rd and 5th positions on the ring, and a methoxy group at the 4th position. It is generally used as a reagent in a variety of chemical syntheses, particularly in the pharmaceutical industry. It exists as a solid at room temperature and it's generally stored in a cool, dry place away from any source of ignition. As with many chemicals, it should be handled with care to avoid any potential harm or skin irritation.

InChI:InChI=1/C8H6F2O2/c1-12-8-6(9)2-5(4-11)3-7(8)10/h2-4H,1H3

Upstream product

• 118276-06-5 3,5-difluoro-4-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 28177-48-2 2,6-difluorophenol 
• 104197-15-1 3,5-difluoro-4-methoxybenzonitrile 

Downstream Products

• 124068-57-1 [1-(3,5-Difluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(2,2-dimethoxy-ethyl)-amine 
• 706786-41-6 (3,5-difluoro-4-methoxy-phenyl)-methanol 
• 706786-42-7 5-(bromomethyl)-1,3-difluoro-2-methoxybenzene 
• 101471-18-5 N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal 
• 95333-60-1 1-(4'-hydroxy-3',5'-difluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione 
• 104197-16-2 1-(4'-methoxy-3',5'-difluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione 
• 527750-92-1 (Z)-3-(3,5-difluoro-4-methoxyphenyl)-2-ethoxy-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 527750-93-2 (Z)-3-(3,5-difluoro-4-methoxyphenyl)-2-propoxy-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 527750-42-1 (E)-3-(3,5-difluoro-4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 524945-14-0 (Z)-3-(3,5-difluoro-4-methoxyphenyl)-2-methoxy-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1224103-94-9 ethyl 3-(3,5-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate 
• 1345017-04-0 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole 
• 1345017-10-8 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride 
• 1564099-06-4 4-(5-chlorobenzo[d]thiazol-2-yl)-2,6-difluorophenyl octanoate 

Relevant articles and documents

ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF

Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

Elemental fluorine. Part 20. Direct fluorination of deactivated aromatic systems using microreactor techniques

Continuous flow microreactor technology has been used for the direct fluorination of a range of deactivated di- and tri-substituted aromatic systems.

A convenient route to new fluorinated photodynamic therapeutic photosensitizers based on meso-tetra(hydroxyphenyl)porphyrins

A general synthetic route was developed for the synthesis of new fluorinated tetra(hydroxyphenyl) porphyrins [5,10,15,20-tetrakis(2-fluoro-3-hydroxyphenyl)porphyrin 10, 5,10,15,20-tetrakis(2,4-difluoro-3-hydroxyphenyl)porphyrin 11, and 5,10,15,20-tetrakis(3,5-difluoro-4-hydroxyphenyl)porphyrin 12], analogues of sensitisers 1-3 which are known to be active in vivo in cancer photodynamic therapy.