66270-97-1 Usage
Description
Phenacyl 4-(bromomethyl)phenylacetate is an organic compound that serves as a key building block in the synthesis of various chemical structures and pharmaceutical agents. It is characterized by its unique molecular structure, which includes a bromomethyl group attached to a phenyl ring, and a phenacyl group connected to an acetate moiety. Phenacyl 4-(bromomethyl)phenylacetate is known for its reactivity and stability, making it a valuable component in the development of new chemical entities and therapeutic agents.
Uses
Used in Pharmaceutical Synthesis:
Phenacyl 4-(bromomethyl)phenylacetate is used as a building block for preparing amino acid PAM linker, which is crucial in the synthesis of peptide-based drugs. The PAM ester is orthogonally stable to cleavage conditions of most protective groups used in FMOC-SPPS (Fmoc Solid Phase Peptide Synthesis), a widely employed method for the synthesis of peptides and peptidomimetics. This stability ensures that the PAM linker can be selectively cleaved without affecting other functional groups in the molecule, allowing for the efficient and precise synthesis of complex peptide structures.
Used in Chemical Research:
Phenacyl 4-(bromomethyl)phenylacetate is also utilized in chemical research as a versatile intermediate for the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable starting material for the preparation of a wide range of chemical entities, including pharmaceuticals, agrochemicals, and specialty chemicals. Researchers can exploit the compound's properties to develop new synthetic routes and methodologies, ultimately leading to the discovery of novel and innovative chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 66270-97-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,7 and 0 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66270-97:
(7*6)+(6*6)+(5*2)+(4*7)+(3*0)+(2*9)+(1*7)=141
141 % 10 = 1
So 66270-97-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H15BrO3/c18-11-14-8-6-13(7-9-14)10-17(20)21-12-16(19)15-4-2-1-3-5-15/h1-9H,10-12H2
66270-97-1Relevant articles and documents
Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds
-
, (2008/06/13)
This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
Design and Synthesis of Multidetachable Resin Supports for Solid-Phase Peptide Synthesis
Tam, James P.,Tjoeng, Foe S.,Merrifield, R. B.
, p. 6117 - 6127 (2007/10/02)
A new and unusually versatile class of supports for solid-phase peptide synthesis has been developed.It contains two orthogonally removable ester bonds, allowing the selective cleavage of the individual bonds by a variety of reagents.The synthetic peptide can be obtained in a free or protected form, or with a removable spacer group still attached at the carboxyl terminus.Two such multidetachable resin supports have been developed in which selective cleavage is by acidolysis, photolysis, or nucleophilic cleavage; they are (1) tert-butoxycarbonylaminoacyl-2-propionyl-copoly(styrene-divinylbenzene) resin (Pop-resin) and tert-butoxycarbonylaminoacyl-4--3-nitrobenzamidomethyl-copoly(styrene-divinylbenzene) resin (Pon-resin).The value of these resins was demonstrated by the stepwise synthesis of Leu-enkephalin and angiotensin II.In addition, applications of this class of supports for fragment synthesis were described.The minimization of side reactions associated with peptide anchored to photolabile resins in the ordinary way was demonstrated.
