6678-00-8

Basic information

• Product Name: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate
• Synonyms: Valeric acid 11β,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester;Hydrocortisone 21-Valerate;XHDMDWMKAYYIRK-FZNHGJLXSA-N
• CAS NO: 6678-00-8
• Molecular Formula: C₂₆H₃₈O₆
• Molecular Weight: 446.5763
• EINECS: 229-716-3
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 6678-00-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 515.91°C (rough estimate)
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.0663 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• Water Solubility: 3.05mg/L(25 oC)
• CAS DataBase Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(CAS DataBase Reference)
• NIST Chemistry Reference: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(6678-00-8)
• EPA Substance Registry System: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate(6678-00-8)

Safety Data

• Hazardous Substances Data: 6678-00-8(Hazardous Substances Data)

Usage

Description

11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate, also known as Hydrocortisone 21-Valerate, is a derivative of Hydrocortisone, a steroid hormone and a glucocorticoid produced by the zona fasciculata of the adrenal gland. It is involved in various physiological processes, including the regulation of blood sugar, immune system suppression, and metabolism of fat, protein, and carbohydrates.

Uses

Used in Pharmaceutical Industry:
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate is used as a pharmaceutical agent for its anti-inflammatory and immunosuppressive properties. It is particularly effective in treating various inflammatory and autoimmune conditions, such as rheumatoid arthritis, lupus, and asthma, by reducing inflammation and suppressing the immune system.
Used in Cosmetic Industry:
In the cosmetic industry, 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate is used as an ingredient in skincare products for its anti-inflammatory and skin-soothing properties. It helps to reduce redness, swelling, and irritation, making it suitable for sensitive and inflamed skin types.
Used in Veterinary Medicine:
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate is also used in veterinary medicine as an anti-inflammatory and immunosuppressive agent for the treatment of various conditions in animals, such as allergies, skin conditions, and inflammatory bowel disease.
Overall, 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-valerate is a versatile compound with applications in various industries, primarily due to its anti-inflammatory and immunosuppressive properties.

Upstream product

• 50-23-7 HYDROCORTISONE 
• 2082-59-9 pentanoic anhydride 

Relevant articles and documents

Relative affinity of 17α-and/or 21-esters and 17α,21-diesters of cortisol for a glucocorticoid receptor from rat thymocytes

The affinity, relative to cortisol, of 17α- and 21-esters and 17α,21-diesters of cortisol for the glucocorticoid receptor of rat thymus cytosol was determined by a competitive binding assay which used [3H]dexamethasone. Esterification of the 21-hydroxy group of cortisol caused a loss of relative affinity to 0.046 for acetate and 0.32 for valerate. Esterification of the 17α-hydroxy group resulted in an increase in relative affinity to 1.14 for acetate, 12.4 for butyrate, and 11.5 for valerate. Diesters had relative affinities which reflected both trends. Thus, the 21-acetate, 21-propionate, 21-butyrate, and 21-valerate of cortisol 17-acetate had relative affinities of 0.036, 0.093, 0.152, and 0.272. The 21-acetate, 21-propionate, and 21-butyrate of cortisol 17-valerate had relative affinities of 0.76, 1.17, and 1.33.