2082-59-9 Usage
Description
Valeric Anhydride, also known as pentanoic anhydride, is an organic compound with the chemical formula (C4H7CO)2O. It is a clear colorless to yellow liquid and is commonly used as a reagent in the synthesis of various organic compounds.
Uses
1. Pharmaceutical Industry:
Valeric Anhydride is used as a synthetic reagent for the production of non-imadazole histamine H3-antagonists, which are important in the development of medications targeting histamine-related conditions.
2. Cancer Research:
Valeric anhydride is used as a reactant in the preparation of millepachine derivatives, a new class of tubulin polymerization inhibitors. These compounds have potential applications in cancer research and treatment.
3. Chemical Synthesis:
Valeric anhydride is used as a reactant to synthesize various compounds, including:
a. Alkyl 9-nitrocamptothecin esters through an esterification reaction, which are potentially useful in the development of anticancer drugs.
b. Modified bismuth metal-organic frameworks (Bi-MOFs), which have potential applications in gas storage, catalysis, and drug delivery.
c. O-acylated chitosan nanofibers (CSNFs) for potential usage in biomaterials and food packaging, due to their enhanced properties such as improved mechanical strength and biocompatibility.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 2082-59-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,8 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2082-59:
(6*2)+(5*0)+(4*8)+(3*2)+(2*5)+(1*9)=69
69 % 10 = 9
So 2082-59-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H18O3/c1-3-5-7-9(11)13-10(12)8-6-4-2/h3-8H2,1-2H3
2082-59-9Relevant articles and documents
ON THE REGIOSELECTIVITY OF THE REACTION OF N-METHOXYCARBONYLPYRIDINIUM CHLORIDE WITH GRIGNARD REAGENTS: HIGHLY REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED N-METHOXYCARBONYL-1,2-DIHYDROPYRIDINES.
Yamaguchi, Ryohei,Nakazono, Yutaka,Kawanisi, Mituyosi
, p. 1801 - 1804 (1983)
Whereas alkyl Grignard reagents undergo 1,2- and 1,4-additions to N-methoxycarbonyl-pyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1,2-addition to afford 2-substituted N-methoxycarbonyl-1,2-dihydropyridines in fair to excellent yields.
Valeric anhydride preparation method
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Paragraph 0019; 0020, (2016/11/17)
The present invention discloses a valeric anhydride preparation method comprising the following steps: (a) adding an organic solvent and valeric acid into a reaction vessel, then adding portionwise dicyclohexyl carbodiimide for reaction at the room temperature for 20 to 40 minutes; and (2) removing solid impurities by filtration, recovering the organic solvent by distillation under reduced pressure, after the the organic solvent is completely recovered, heating for distilling under reduced pressure to obtain an object product valeric anhydride. The method uses the valeric acid and the dicyclohexyl carbodiimide for reaction for preparation of the valeric anhydride, the separation process is simple, the obtained valeric anhydride is high in quality, and the valeric anhydride purity reaches 99.3%.
Synthesis of α-diazoketone by the action of diazoalkanes on butyric anhydride
Chakraborty, Saurabh,Agarwal
body text, p. 1573 - 1575 (2011/10/31)
Butyric anhydride reacts with diazo-n-alkanes In dry ether at 0°C gave 1-diazo-1-n-alkyl pentanones.
