671816-04-9

Basic information

• Product Name: (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide
• Synonyms: (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide;[(1R)-1-[trans-4-[(4-PyridinylaMino)carbonyl]cyclohexyl]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester;N-Boc-Y-27632;CarbaMic acid, N-[(1R)-1-[trans-4-[(4-pyridinylaMino)carbonyl]cyclohexyl]ethyl]-, 1,1-diMethylethyl ester
• CAS NO: 671816-04-9
• Molecular Formula: C₁₉H₂₉N₃O₃
• Molecular Weight: 347.45186
• Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators
• Mol File: 671816-04-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 90-92°C
• Boiling Point: 547.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.125±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.50±0.46(Predicted)
• CAS DataBase Reference: (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide(671816-04-9)
• EPA Substance Registry System: (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide(671816-04-9)

Safety Data

• Hazardous Substances Data: 671816-04-9(Hazardous Substances Data)

Usage

Description

(1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide is a complex organic compound with a unique molecular structure. It is characterized by its off-white solid appearance and is known for its protective properties towards Y-27632, a Rho kinase inhibitor (ROCK). (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide is particularly useful in the treatment of ischemia-reperfusion disorders, showcasing its potential in the pharmaceutical industry.

Uses

Used in Pharmaceutical Applications:
(1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide is used as a protective agent for Y-27632, a Rho kinase inhibitor (ROCK), for the treatment of ischemia-reperfusion disorders. Its protective properties help maintain the stability and efficacy of Y-27632, making it a valuable component in the development of therapeutic strategies for such disorders.
Used in Chemical Research:
In the field of chemical research, (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide serves as a valuable compound for studying its unique molecular structure and properties. Its off-white solid appearance and complex structure make it an interesting subject for further investigation and potential development of new applications in various industries.
Used in Drug Delivery Systems:
Similar to gallotannin, (1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide could potentially be utilized in drug delivery systems. Its protective properties towards Y-27632 may allow for the development of novel drug delivery systems that enhance the compound's delivery, bioavailability, and therapeutic outcomes, particularly in the treatment of ischemia-reperfusion disorders.

Upstream product

• 504-24-5 4-aminopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141836-50-2 trans-[4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-methanol 
• 141836-47-7 4-(((tert-butyldimethylsilyl)oxy)methyl)cyclohexane carbaldehyde 
• 672314-62-4 (R)-N-tert-butyloxycarbonyl-1-[4'-(hydroxymethyl)cyclohexyl]ethan-1-amine 
• 672314-51-1 (R)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-40-8 (R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine 
• 672314-58-8 (R)-N-tert-butyloxycarbonyl-1-[4'-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-45-3 (1R,1'R)-N-[1'-(phenyl)ethyl]-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 671815-99-9 (1R,4r)-4-((R)-1-((tert-butoxycarbonyl)amino)ethyl)cyclohexanecarboxylic acid 
• 149004-75-1 trans-(R)-4-(1-aminoethyl)cyclohexanecarboxylic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 36283-44-0 N-acetyl-1-phenylethylamine 
• 88146-37-6 (R)-N-(1-(4-acetylphenyl)ethyl)acetamide 

Downstream Products

• 129830-38-2 (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride 
• 742043-06-7 R-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)-cyclohexanecarboxamide 

Relevant articles and documents

A Rho kinase inhibitor Y27632 method for the preparation of compounds

The invention discloses a preparation method of a Rho kinase inhibitor Y27632 compound. Chirality of amine is constructed through a CBS reduction method high in selectivity to obtain amine with high optical purity, thus effectively and rapidly realizing s

1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES

Allylic compounds represented by the formula (I) are provided, wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.