67412-96-8

Basic information

• Product Name: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE
• Synonyms: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE;(R)-a-Amino-4-methoxybenzeneacetamide HCl
• CAS NO: 67412-96-8
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 182.21966
• Mol File: 67412-96-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 371.171°C at 760 mmHg
• Flash Point: 206.098°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• CAS DataBase Reference: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE(67412-96-8)
• EPA Substance Registry System: R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE(67412-96-8)

Safety Data

• Hazardous Substances Data: 67412-96-8(Hazardous Substances Data)

Usage

General Description

R-Alpha-Amino-4-Methoxybenzene Acetamide is a chemical compound that belongs to the class of acetamides and contains an alpha-amino substituent. It is a white to off-white solid at room temperature and is commonly used as a building block in the synthesis of various pharmaceutical compounds. This chemical is known for its analgesic and anti-inflammatory properties, making it a valuable ingredient in the development of pain relief medications. Additionally, it is also used in the production of dyes, pigments, and other organic compounds. R-Alpha-Amino-4-Methoxybenzene Acetamide is a versatile chemical with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C9H12N2O2/c1-13-7-4-2-6(3-5-7)8(10)9(11)12/h2-5,8H,10H2,1H3,(H2,11,12)/t8-/m1/s1

Upstream product

• 76986-15-7 2-amino-2-(4-methoxyphenyl)acetamide 
• 42456-26-8 2-amino-2-(4-methoxyphenyl)acetonitrile 
• 60827-77-2 (R)-(N-benzyloxycarbonyl)-p-methoxyphenylglycine 

Downstream Products

• 1000307-35-6 2-(R)-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)acetylamino]-acetamide 

Relevant articles and documents

BMS-201620: A selective beta 3 agonist

A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-201620 (39), a potent β3 full agonist (Ki=93nM, 93% activation). Based on its favorable safety profile, BMS-201620 was chosen for clinical evaluation.

Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformations of nitriles

Under very mild conditions, the Rhodococcus sp. AJ270-catalysed biotransformation of arylglycine nitriles 1, prepared easily from the reaction of substituted benzaldehydes, ammonium chloride and potassium cyanide, proceeded efficiently to produce optically active D-arylglycine amides 2 and L-arylglycines 3 in excellent yields with enantiomeric excesses higher than 99%.