675109-26-9

Basic information

• Product Name: 6-bromoisoindolin-1-one
• Synonyms: 6-bromoisoindolin-1-one;6-Bromo-2,3-dihydroisoindolin-1-one;1H-Isoindol-1-one, 6-broMo-2,3-dihydro-;6-broMo-2,3-dihydro-1H-isoindol-1-one;6-BroMo-2,3-dihydro-isoindol-1-one;6-BroMoisoindolin-1-one, 95+%
• CAS NO: 675109-26-9
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.045
• Mol File: 675109-26-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 431.694 °C at 760 mmHg
• Flash Point: 214.881 °C
• Appearance: /
• Density: 1.666 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.87±0.20(Predicted)
• CAS DataBase Reference: 6-bromoisoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromoisoindolin-1-one(675109-26-9)
• EPA Substance Registry System: 6-bromoisoindolin-1-one(675109-26-9)

Safety Data

• Hazardous Substances Data: 675109-26-9(Hazardous Substances Data)

Usage

General Description

6-Bromoisoindolin-1-one is a specific type of organic compound that belongs to the class of chemicals known as isoindolones, characterized by an isoindoline ring system that carries a ketone at the 1-position. Being a brominated derivative of isoindolin-1-one, it has a bromine atom attached at the 6-position. It is a synthetic compound that often acts as a crucial building block in organic synthesis, particularly in pharmaceutical research for creating new drug molecules. Its properties, uses, or safety measures are typically detailed by suppliers or entities such as substance databases or safety data sheets.

InChI:InChI=1/C8H6BrNO/c9-6-2-1-5-4-10-8(11)7(5)3-6/h1-3H,4H2,(H,10,11)

Upstream product

• 79669-50-4 methyl 2-methyl-5-bromobenzoate 
• 79670-17-0 methyl 2-bromomethyl-5-bromobenzoate 
• 480-91-1 oxisoindole 
• 87384-76-7 N-(4′-bromobenzyl)-2-methylpropan-2-amine 
• 118-90-1 ortho-methylbenzoic acid 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 1200444-64-9 N-(4-bromobenzyl)picolinamide 
• 1972-28-7 diethylazodicarboxylate 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 1004294-80-7 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one 
• 862081-33-2 6-{6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-yl}-2,3-dihydroisoindol-1-one 
• 1338478-30-0 6-(benzyl(ethyl)amino)-2-methylisoindolin-1-one 
• 1416797-49-3 C₂₃H₁₅F₆N₃O₂ 
• 1313399-38-0 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one 

Relevant articles and documents

ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

Preparation method for 5-bromoisoindoline hydrochloride

The invention provides a preparation method for 5-bromoisoindoline hydrochloride. The method comprises the following steps: firstly esterifying 5-bromine-2-methyl benzoic acid, and then brominating methyl NBS, cyclizing and reducing with borane, thereby o

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).