67639-92-3Relevant articles and documents
Copper-catalysed asymmetric conjugate addition of organometallic reagents to linear enones
Bennett, Simon M.W.,Brown, Stephen M.,Cunningham, Anthony,Dennis, Michael R.,Muxworthy, James P.,Oakley, Michael A.,Woodward, Simon
, p. 2847 - 2855 (2000)
Methods for enantioselective 1,4-addition of main-group organometallics to linear enones are overviewed. Thiourethane and thioether 1,1-binaphthyl- based ligands are effective for copper-catalysed 1,4-addition of ZnEt2 and AlR3 (R=Me, Et) to trans-alkyl-3-en-2-ones; enantioselectivities of up to 72% e.e. are attained. In comparison 1,4-addition of ZnEt2 to 2- cyclohexenone proceeds in up to 77% e.e. with the same ligand family. (C) 2000 Elsevier Science Ltd.
Amino-sugar modular ligands - Useful cores for the formation of asymmetric copper 1,4-addition catalysts
De Roma, Antonella,Ruffo, Francesco,Woodward, Simon
supporting information; experimental part, p. 5384 - 5386 (2009/03/11)
Modular phosphine ligands, synthesised rapidly from commercial N-acetylglucosamine, are very effective in copper(I)-catalysed 1,4-additions of ZnR2 to linear aliphatic enones (87-95% ee). The Royal Society of Chemistry.
Uncatalyzed conjugate additions of diorganozincs in N- methylpyrrolidinone
Reddy, Ch. Kishan,Devasagayaraj,Knochel
, p. 4495 - 4498 (2007/10/03)
Diorganozincs efficiently add to enones, unsaturated nitriles and nitroolefins in a mixture of THF and NMP furnishing the corresponding Michael adducts in good to excellent yields.