69142-64-9Relevant articles and documents
SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
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Paragraph 0774; 0775, (2017/04/04)
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Efficient synthesis of tert-Butyl (6-Formylpyridin-2-yl)carbamic acid
Majgier-Baranowska, Helena,Li, Bing,Peet, Norton P.
, p. 1173 - 1180 (2013/03/29)
We have developed an efficient four-step synthesis of tert-butyl (6-formylpyridin-2-yl)carbamic acid (1) in 80% overall yield using inexpensive starting material and reagents and no air-sensitive reagents. Column chromatography was not required for purification of the intermediates or the final product.
3-SUBSTITUED IMIDAZO (4, 5-B) PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS
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Page/Page column 78, (2011/10/10)
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e