6926-51-8

Basic information

• Product Name: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE;5-(4-METHOXY-PHENYL)-2H-TETRAZOLE
• CAS NO: 6926-51-8
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.18
• Mol File: 6926-51-8.mol
• Article Data: 151

Chemical Properties

• Melting Point: 235-238°C
• Boiling Point: 365.2°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 1.6E-05mmHg at 25°C
• Refractive Index: 1.591
• BRN: 152619
• CAS DataBase Reference: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(6926-51-8)
• EPA Substance Registry System: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(6926-51-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 6926-51-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 1565, 1984 DOI: 10.1021/jm00378a007Tetrahedron Letters, 38, p. 1257, 1997 DOI: 10.1016/S0040-4039(97)00052-X

InChI:InChI=1/C8H8N4O/c1-13-7-4-2-6(3-5-7)8-9-11-12-10-8/h2-5H,1H3,(H,9,10,11,12)

Upstream product

• 829-48-1 4-methoxy-benzimidic acid ethyl ester 
• 874-90-8 4-methoxybenzonitrile 
• 624-84-0 formic acid hydrazide 
• 3424-93-9 4-methoxyphenylacetamide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 207301-15-3 1-(4-methoxyphenyl)-4-ferrocenylmethylenetetrazolium fluoroborate 
• 123-11-5 4-methoxy-benzaldehyde 
• 2362-64-3 p-methoxythiobenzamide 
• 3717-21-3 p-methoxyl benzaldoxime 
• 105-13-5 4-Methoxybenzyl alcohol 
• 696-62-8 para-iodoanisole 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 4648-54-8 trimethylsilylazide 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 2039-09-0 3,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 104186-18-7 4-[5-(4-Methoxy-phenyl)-tetrazol-2-ylmethyl]-2,6-dimethyl-phenol 
• 92595-39-6 4-Hydroxy-3-methoxy-5-[5-(4-methoxy-phenyl)-tetrazol-2-ylmethyl]-benzaldehyde 
• 137898-60-3 5-(4-Methoxy-phenyl)-1-trityl-1H-tetrazole 
• 91658-53-6 [5-(4-Methoxy-phenyl)-tetrazol-1-yl]-phenyl-methanone 
• 91658-59-2 [5-(4-Methoxy-phenyl)-tetrazol-2-yl]-phenyl-methanone 
• 43131-50-6 methyl 4-(2-methyl-2H-tetrazol-5-yl)phenyl ether 
• 43131-46-0 5-(4-methoxyphenyl)-1-methyl-1H-tetrazole 
• 117594-33-9 N-[1-[5-(4-Methoxy-phenyl)-tetrazol-2-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine 
• 117594-21-5 N-[1-[5-(4-Methoxy-phenyl)-tetrazol-1-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine 
• 73670-61-8 2-(4-pentenyl)-5-(p-methoxyphenyl)tetrazole 
• 113246-32-5 N-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-N-phenyl-N'-[1-phenyl-meth-(Z)-ylidene]-hydrazine 
• 253341-71-8 5-(4-Methoxy-phenyl)-1-prop-2-ynyl-1H-tetrazole 

Relevant articles and documents

Synthesis, crystal structure and investigation of the catalytic and spectroscopic properties of a Zn(II) complex with coumarin-hydrazone ligand

A Zn(II) complex with coumarin-hydrazone ligand, [ZnCl(HL)(CH3OH)0.76(H2O)0.24]·0.24(CH3OH) (1), was synthesized from the reaction of equimolar amount of ZnCl2·4H2O and (E)-2-hyd

Sustainable and recyclable magnetic nanocatalyst of 1,10-phenanthroline Pd(0) complex in green synthesis of biaryls and tetrazoles using arylboronic acids as versatile substrates

A magnetic nanocatalyst was purveyed as a heterogeneous recoverable palladium-based catalyst anchored on green, sustainable and phosphine free support. Resulted Fe3O4@SiO2-Phen-Pd(0) nanocatalyst bearing powerful phenanthroline ligand was thoroughly characterized by physicochemical approaches like UV–vis, FT-IR, EDX, XRD, TGA, ICP, VSM, DLS, FESEM, and TEM analyses. After finding trustable data, the obtained magnetic catalyst was considered to be applied in the Suzuki-Miyaura type C-C couplings and getting corresponding tetrazoles using arylboronic acid derivatives as alternate precursors of aromatic halides and stupendous data were observed.

The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route

Today, most synthetic methods are aimed at carrying out reactions under more efficient conditions and the realization of the twelve principles of green chemistry. Due to the importance and widespread applications of tetrazoles in various industries, especially in the field of pharmaceutical chemistry, and the expansion of the use of nanocatalysts in the preparation of valuable chemical reaction products, we decided to use an (Fe3O4@NFC@NSalophCu)CO2H nanocatalyst in this project. In this study, the synthesis of the nanocatalyst (Fe3O4@NFC@NSalophCu)CO2H was explained in a step-by-step manner. Confirmation of the structure was obtained based on FT-IR, EDX, FE-SEM, TEM, XRD, VSM, DLS, TGA, H-NMR, and CHNO analyses. The catalyst was applied to the synthesis of 5-substituted-1H-tetrazole and 1-substituted-1H-tetrazole derivatives through multi-component reactions (MCRs), and the performance was assessed. With advances in science and technology and increasing environmental pollution, the use of reagents and methods that are less dangerous for the environment has received much attention. Therefore, following green chemistry principles, with the help of the (Fe3O4@NFC@NSalophCu)CO2H salen complex as a nanocatalyst that is recyclable, cheap, safe, and available, the use of water as a green solvent, and reduced reaction times, the synthesis of tetrazoles can be achieved.