842-79-5

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole;methyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl ether;2-Phenyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS NO: 842-79-5
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.26798
• EINECS: 212-675-0
• Mol File: 842-79-5.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 413.3°C at 760 mmHg
• Flash Point: 203.8°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(842-79-5)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(842-79-5)

Safety Data

• Hazardous Substances Data: 842-79-5(Hazardous Substances Data)

Usage

Description

2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is a heterocyclic chemical compound that belongs to the oxadiazole family. It features a five-membered ring structure with one oxygen and two nitrogen atoms, along with a 4-methoxyphenyl and a phenyl group attached to it. 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole has demonstrated potential applications across various fields, such as pharmaceuticals, agrochemicals, and material science, due to its unique electronic and optical properties as well as its promising biological activities.

Uses

Used in Pharmaceutical Applications:
2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is used as a pharmaceutical agent for its antimicrobial, anticancer, and anti-inflammatory properties. Its diverse biological activities make it a promising candidate for the development of new drugs to treat various diseases and conditions.
Used in Agrochemical Applications:
In the agrochemical industry, 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is used as a component in the development of pesticides and other agrochemical products. Its antimicrobial properties can contribute to the control of pests and diseases in agriculture, enhancing crop protection and yield.
Used in Material Science Applications:
2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is used as a key component in the development of organic electronic materials. Its unique electronic and optical properties make it suitable for applications in organic light-emitting diodes (OLEDs), organic solar cells, and other electronic devices, contributing to advances in the field of material science and technology.
Overall, the diverse range of applications for 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole makes it a valuable compound in the field of chemical research and development, with potential to impact various industries.

InChI:InChI=1/C15H12N2O2/c1-18-13-9-7-12(8-10-13)15-17-16-14(19-15)11-5-3-2-4-6-11/h2-10H,1H3

Upstream product

• 6781-59-5 1-benzoyl-2-(4-methoxybenzoyl)hydrazine 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 77-78-1 dimethyl sulfate 
• 41980-89-6 4-methoxy-benzoic acid N'-thiobenzoyl-hydrazide 
• 59635-52-8 N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 6926-51-8 5-(4-methoxyphenyl)-2H-tetrazole 
• 60413-24-3 2,5-bis-(4-methoxy-phenyl)-3-methyl-[1,3,4]oxadiazolium; toluene-4-sulfonate 
• 613-94-5 benzoic acid hydrazide 
• 51651-81-1 4-methoxy-benzoic acid benzylidenehydrazide 
• 6926-51-8 5-(4-methoxyphenyl)-1H-tetrazole 
• 93-97-0 benzoic acid anhydride 
• 14850-86-3 N'-(4-methoxybenzylidene)benzohydrazide 

Downstream Products

• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 1456-67-3 2-(4'-methoxyphenyl)-5-phenyl-1,3,4-thiadiazole 
• 173865-05-9 2-methyl-acrylic acid 4-(5-phenyl-[1,3,4]oxadiazol-2-yl)phenyl ester 
• 335276-13-6 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-dimethyl benzene 
• 335276-14-7 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-bis(bromomethyl)benzene 
• 1239666-99-9 C₂₉H₃₆N₂O₄ 
• 1239666-98-8 11-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-undecan-1-ol 

Relevant articles and documents

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.