6941-21-5

Basic information

• Product Name: N-tert-butyl-2-phenylacetamide
• Synonyms: benzeneacetamide, N-(1,1-dimethylethyl)-
• CAS NO: 6941-21-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 6941-21-5.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 349.4°C at 760 mmHg
• Flash Point: 208.6°C
• Density: 0.984g/cm³
• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: N-tert-butyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-2-phenylacetamide(6941-21-5)
• EPA Substance Registry System: N-tert-butyl-2-phenylacetamide(6941-21-5)

Safety Data

• Hazardous Substances Data: 6941-21-5(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 27151-60-6 1-t-butyl-3-phenylaziridin-2-one 
• 1589-82-8 phenylmagnesium bromide 
• 110-06-5 di-tert-butyl disulfide 
• 28481-53-0 2-hydroxyethyl 2-phenylacetate 
• 75-64-9 tert-butylamine 
• 103-80-0 phenylacetyl chloride 
• 103-81-1 Benzeneacetamide 
• 103-82-2 phenylacetic acid 
• 540-88-5 acetic acid tert-butyl ester 
• 201230-82-2 carbon monoxide 
• 100-39-0 benzyl bromide 

Downstream Products

• 24070-10-8 2-methyl-N-phenethylpropan-2-amine 
• 5466-04-6 N-Isobutyryl-C-phenylglycin 
• 94430-23-6 2-tert-butoxy-N-tert-butyl-2-phenylethanamide 
• 70161-03-4 tert-butyl-methyl-phenethyl-amine 
• 103-81-1 Benzeneacetamide 
• 87451-13-6 (S)-1-tert-Butyl-3-phenylazetidin-2-one 
• 99-87-6 4-methylisopropylbenzene 

Relevant articles and documents

A convenient synthesis of N-tert-butyl amides by the reaction of di-tert-butyl dicarbonate and nitriles catalyzed by Cu(OTf)2

The utility of Cu(OTf)2 as the catalyst for the synthesis of a series of N-tert-butyl amides in excellent isolated yields via the reaction of nitriles (alkyl, aryl, benzyl, and furyl nitriles) with di-tert-butyl dicarbonate is described. Cu(OTf)2 is a highly stable and efficient catalyst for the present Ritter reaction under solvent-free conditions at room temperature.

Organophotoredox-Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol

The combination of an organic photocatalyst [4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6 dicyanobenzene) or 5MeOCzBN (2,3,4,5,6-pentakis(3,6-dimethoxy-9 H-carbazol-9-yl)benzonitrile)], quinuclidine, and tetra-n-butylammonium phosphate (hydrogen-bonding catalyst) was employed for amide bond formations. The hydrogen-bonded OH group activated the adjacent C?H bond of alcohols towards hydrogen atom transfer (HAT) by a radical species. The quinuclidinium radical cation, generated through single-electron oxidation of quinuclidine by the photocatalyst, employed to abstract a hydrogen atom from the α-C?H bond of alcohols selectively due to a polarity effect-produced α-hydroxyalkyl radical, which subsequently converted to the corresponding aldehyde under aerobic conditions. Then the coupling of the aldehyde and an amine formed a hemiaminal intermediate that upon photocatalytic oxidation produced the amide.

Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides

Complex CpRuCl(PPh3)2 catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry. Stoichiometric studies reveal that the true catalysts of the processes are the vinylidene cations [CpRu(=C=CHR)(PPh3)2]+ which are oxidized to the Ru(η2-CO)-ketenes by the N-oxide. Finally, nucleophilic additions of primary and secondary amines to the free ketenes yield the corresponding amides.