701979-19-3

Basic information

• Product Name: Benzonitrile, 4-[1-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-1,2,4-triazol-3-yl]-
• CAS NO: 701979-19-3
• Molecular Formula: C23H15N7
• Molecular Weight: 389.419
• Mol File: 701979-19-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[1-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-1,2,4-triazol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[1-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-1,2,4-triazol-3-yl]-(701979-19-3)
• EPA Substance Registry System: Benzonitrile, 4-[1-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-1,2,4-triazol-3-yl]-(701979-19-3)

Safety Data

• Hazardous Substances Data: 701979-19-3(Hazardous Substances Data)

Upstream product

• 623-26-7 terephthalonitrile 
• 5315-24-2 1-(6-methylpyridin-2-yl)hydrazine 
• 258503-93-4 quinoxaline-6-carbonyl chloride 
• 75782-99-9 4-cyanobenzimidic acid methyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel 2-pyridinyl-[1,2,4] triazoles as inhibitors of transforming growth factor β1 type 1 receptor

A series of 2-pyridinyl-[1,2,4]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 12b showed significant ALK5 inhibition (SBE-Luciferase, 73%; p3TP-Luciferase, 85%) at a concentration of 5μM that is comparable to that of SB-431542 (SBE-Luciferase, 79%; p3TP-Luciferase, 88%), but weak p38α MAP kinase inhibition (4%) at a concentration of 10μM that is much lower than that of SB-431542 (54%). The binding mode of 12b generated by flexible docking studies revealed that the structure of 12b is a good fit into the (NPC-30345)-binding cavity of ALK5.