7242-56-0

Basic information

• Product Name: DIISOBUTYL METHYLPHOSPHONATE
• Synonyms: Diisobutylmethylphosphonate,97%;Methylphosphonic acid diisobutyl ester;DIISOBUTYL METHYLPHOSPHONATE
• CAS NO: 7242-56-0
• Molecular Formula: C9H21O3P
• Molecular Weight: 208.24
• Mol File: 7242-56-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 253.8 °C at 760 mmHg
• Flash Point: 121.3 °C
• Appearance: /Liquid
• Density: 0.969 g/cm³
• CAS DataBase Reference: DIISOBUTYL METHYLPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIISOBUTYL METHYLPHOSPHONATE(7242-56-0)
• EPA Substance Registry System: DIISOBUTYL METHYLPHOSPHONATE(7242-56-0)

Safety Data

• Hazardous Substances Data: 7242-56-0(Hazardous Substances Data)

Usage

Uses

It is an important raw material and Pharmaceutical intermediate.

InChI:InChI=1/3C41H39P3.4C4H4N2O2S.3CN.4Fe/c3*1-41(32-42(35-20-8-2-9-21-35)36-22-10-3-11-23-36,33-43(37-24-12-4-13-25-37)38-26-14-5-15-27-38)34-44(39-28-16-6-17-29-39)40-30-18-7-19-31-40;4*1-9(7,8)4(2-5)3-6;3*1-2;;;;/h3*2-31H,32-34H2,1H3;4*4H,1H3;;;;;;;/q;;;;;;;3*-1;;;;/p+9

Upstream product

• 74-83-9 methyl bromide 
• 1606-96-8 triisobutyl phosphite 
• 74-88-4 methyl iodide 
• 676-97-1 methylphosphonic acid dichloroanhydride 
• 78-83-1 2-methyl-propan-1-ol 
• 1189-24-8 diisobutyl phosphite 
• 993-13-5 methylphosphonic acid 

Relevant articles and documents

P-Toluenesulfonic acid-Celite as a reagent for synthesis of esters of alkylphosphonic acids under solvent-free conditions

The coupling reaction of alkylphosphonic acids and alcohols on the surface of p-toluenesulfonic acid-Celite under mild and solvent-free conditions gave the corresponding phosphonates in excellent yields. This method provides a useful rapid synthesis of phosphonates for use in the unambiguous identification of chemical warfare agents.

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents

Enzymes that efficiently hydrolyze highly toxic organophosphorus nerve agents could potentially be used as medical countermeasures. As sufficiently active enzymes are currently unknown, we synthesized twelve fluorogenic analogues of organophosphorus nerve agents with the 3-chloro-7-oxy-4- methylcoumarin leaving group as probes for high-throughput enzyme screening. This set included analogues of the pesticides paraoxon, parathion, and dimefox, and the nerve agents DFP, tabun, sarin, cyclosarin, soman, VX, and Russian-VX. Data from inhibition of acetylcholinesterase, in vivo toxicity tests of a representative analogue (cyclosarin), and kinetic studies with phosphotriesterase (PTE) from Pseudomonas diminuta, and a mammalian serum paraoxonase (PON1), confirmed that the analogues mimic the parent nerve agents effectively. They are suitable tools for high-throughput screens for the directed evolution of efficient nerve agent organophosphatases.

Oligophosphonic acids, oligophosphinic acids, and process of preparation

This invention relates to a process for preparing oligophosphonic or oligophosphinic acids or esters or salts thereof which comprises reacting an alkali metal ester of phosphorous acid or an alkali metal ester of arylphosphonous or alkylphosphonous acid with an olefin polyhalide and, optionally, saponifying the resultant product.